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OverviewExcess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad rangeof basic science and medical implications of homocysteine-containing proteins for health and disease. Full Product DetailsAuthor: Hieronim JakubowskiPublisher: Springer Verlag GmbH Imprint: Springer Verlag GmbH Edition: Softcover reprint of the original 1st ed. 2013 Dimensions: Width: 15.50cm , Height: 1.00cm , Length: 23.50cm Weight: 2.818kg ISBN: 9783709117200ISBN 10: 3709117208 Pages: 166 Publication Date: 15 July 2015 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of Contents1. Introduction.- 2. Homocysteine. Chemical Synthesis.- Physicochemical Properties.- Quantification Methods.- Metabolic Pathways.- Clinical significance.- 3. Homocysteine Thiolactone.- Chemical Synthesis.- Physicochemical Properties.- Quantification Methods.- Biological Formation and Turnover.- Clinical Significance.- 4. N-Homocysteinylated Proteins.- Functional Consequences.- Albumin.- Fibrinogen.- Cytochrome c.- Other Proteins.- Quantification Methods.- Total N-homocysteinylation assays.- Site-specific N-homocysteinylation assays.- Formation in vivo.- Turnover to N -Homocysteinyl-lysine.- Biological Consequences and Clinical Significance.- 5. S-Homocysteinylated Proteins.- Formation in vitro.- Functional Consequences.- Annexin.- Metallothionein.- Fibrilin, Fibronectin, Tropoelastin.- Detection in vivo.- Biological consequences.- Conclusions.- References.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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