Overview

In late 2025 and early 2026, South Carolina experienced one of the most alarming measles outbreaks in decades. With a staggering 68% surge in cases within a single week, the outbreak highlighted the fragility of public health progress in a modern, highly mobile society. Centered in Spartanburg County and the Upstate region, the outbreak spread rapidly due to low vaccination coverage, holiday travel, and community gatherings, ultimately impacting neighboring states.This book provides a comprehensive account of the outbreak, exploring the epidemiology, case distribution, and timeline of events, as well as the public health response. Through expert analysis, the book examines the biological, social, and behavioral factors that allowed measles to surge, offering insight into vaccine hesitancy, community behavior, and systemic vulnerabilities. It also addresses the broader implications for national policy, public health preparedness, and disease prevention strategies, providing lessons applicable to future outbreaks of measles and other vaccine-preventable diseases. With in-depth narrative, expert perspectives, and actionable recommendations, this book is an essential resource for public health professionals, policymakers, healthcare providers, educators, and concerned citizens. It illustrates not only the dangers posed by lapses in vaccination coverage but also the critical importance of community engagement, trust, and proactive disease prevention in safeguarding public health.

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