Overview

The principal objective of this text is to inform scientists and educated lay audience of the documented involvement of the nervous system in AIDS and the tremendous opportunities for basic neuroscience research in this evolving area. Recent evidence indicates that HIV infection results in the perturbation of the blood-brain barrier potentially facilitating the entry of HIV into the brain parenchyma and directly causing neuronal dysfunction and ultimate death. In addition, recently established models of AIDS in monkeys, cats and mice faithfully recapitulate aspects of neuropathophysiology of HIV infection in humans, thereby providing new opportunities for research in NeuroAIDS.

Full Product Details

Author:   Michael B. A. Oldstone ,  Ljubisa Vitkovic
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   v.202
Weight:   0.570kg
ISBN:  

9783540591177

ISBN 10:   3540591176
Pages:   292
Publication Date:   16 August 1995
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Temporarily unavailable  
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Table of Contents

List of Contents.- A The Human Problem: HIV, Neuropsychiatric Disorders, and Dementia.- The Pathogenesis of HIV Infections of the Brain.- Neurocognitive Disorders in HIV-1 Infection.- AIDS Dementia Complex and HIV-1 Brain Infection: A Pathogenetic Framework for Treatment and Evaluation.- Quantitative Neuropathologic Assessment of HIV-1 Encephalitis.- Penetration of Solutes, Viruses, and Cells Across the Blood-Brain Barrier.- Cytotoxic T Lymphocytes and HIV-1-Related Neurologic Disorders.- Distinct HIV-1 env Sequences Are Associated with Neurotropism and Neurovirulence.- Role for Astrocytosis in HIV-1-Associated Dementia.- Therapeutic Approaches to HIV Infection Based on Virus Structure and the Host Pathogen Interaction.- B Lentivirus Animal Models of HIV Central Nervous System Disease.- Neurobiology of Simian and Feline Immunodeficiency Virus Infections.- Selected Models of HIV-Induced Neurological Disease.- Feline Immunodeficiency Virus as a Model for Study of Lentivirus Infection of the Central Nervous System.- Transgenic Models to Assess the Neuropathogenic Potential of HIV-1 Proteins and Cytokines.- C Tissue Culture and Animal Models to Generate Basic Concepts in Viral Immune Cell: Central Nervous System Interactions.- Virus Entry and Release in Polarized Epithelial Cells.- Traffic of Hematogenous Cells Through the Central Nervous System.- Principles of Cytotoxic T Lymphocyte Induction and Recognition.- Virus-Neuron-Cytotoxic T Lymphocyte Interactions.

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