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Foreword Preface CONTENTS PART-I Cha pter-l: In trod uction Introduction Brief History Global Epidemic Summary References Chapter-2: Morphology and Life Cycle of IV Introduction Morphology of the Mature Virion Replication Cycle of HIV-I Early Phase Role of CD4 molecule in infection Role of chemokine receptors during infection Late Phase Summary References Chapter-3: Functions of Structural Components Introduction Immature virus Mature virus Envelop Proteins TM (gp41) SU (gpI20) Structural Proteins Matrix protein (MA) Capsid protein (CA) Nucleocaspid protein (NC) P6 Proteinf xii HIV-AIDS and Bioactive Natural Products Viral Enzymes Protease (PR) Reverse transcriptase (RT) Integrase (IN) Accessory Proteins Nef Tat Rev Vpr Vpu Vif Phylogenetic Tree of HIV Sequence Summary References Chapter-4: Immune Response to HIV Infection Introduction Antigen presenting Cells Lymphatic Tissues Cellular immune response to HIV Role of CD4+ T lymphocytes or helper T cells in Immune response to HIV Humoral immune responses to HIV-I Major Histocompatibility Complex (MHC) Sumlnary References Chapter-S: Clinical Spectrum and Pathogenesis Introduction Dynamism of HIV Infection Signs and Symptoms Diagnosis Clinical Manifestation Summary References Chapter-6: Management of AIDS Introduction Antiretroviral Therapy Objective of antiretroviral therapy Initiation for antiretroviral therapy Early and delayed initiation of therapy for the Asymptomatic HIV infected patient Contents xiii Combination Therapy Rationale for Combination Therapy In vitro assays Nucleoside Analogues of Reverse Transcriptase Inhibitors Protease Inhibitors Non-Nucleoside Reverse Transcriptase Inhibitors Entry Inhibitors Attachment inhibitor Coreceptor Antagonist Fusion Inhibitors Integrase Inhibitors Other Drugs of Use Sumlnary References Chapter-7: Vaccines for HIV Introduction Conventional Vaccine Designs Whole virus vaccine Subunit vaccine Novel Vaccine Design Live vector vaccine DNA Vaccine Priming and boosting approach The polyepitopes (polytope) vaccination Other Strategy Modulation of T cell response Therapeutic vaccination Autologous vaccines Heterologous vaccines Summary References PART-II Chapter-8: Role of Natural Products in Treatment & Management of AIDS Introduction Ayurvedic Approach Chinese Approach Phytotherapeutic Approach Summary References Chapter-9: Proteins Introduction Lectins Macrocyclic Peptides Ribosome Inactivating Proteins Antifungal Proteins Summary References Chapter-IO: Alkaloids Introduction Pyridine and Piperidine Alkaloids Quinoline Alkaloids Isoquinoline Alkaloids Indole Alkaloids Pyrallo Phenanthridine Alkaloids Aporphine Alkaloids Morphinan Alkaloids Miscellaneous Alkaloids Alkaloids from Marine Source Nitrogenous Compounds from Microorganisms Summary References Chapter-ll: Polysaccharides Introduction Heparin Sulphate Dextran Sulphate Polysaccharide from Tea Leaves Polysaccharide from Mushroom Source Sulpholipids Polysaccharide from Marine Source Polysaccharide from Microalgae Summary References Chapter-12: Tannins Introduction Catechin Derivatives Hydrolysable Tannins Other Polyphenolics Summary References Chapter-13: Flavonoids Introduction Anti-HIV Flavonoids Baicalin Anti-HIV Biflavonoids Other Anti-HIV Flavonoids Summary References Chapter-14: Lignans Introduction Dibenzylbutadiene Lignans Dibenzocyc1ooctadiene Lignans Dibenzylbutyrolactone Lignans Summary References Chapter-IS: Coumarins Introduction Calanolides Soulattrolide Inophyllums Cordatoilides Dihydroisocoumarins Suksdorfin Khellactone Derivatives Integrase Inhibitory Activity of Coumarins Summary References Chapter-16: Terpenoid

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