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OverviewHeritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight. Table of Contents Front Matter Summary 1 Introduction 2 The State of the Science 3 Potential Applications of Heritable Human Genome Editing 4 A Translational Pathway to Limited and Controlled Clinical Applications of Heritable Human Genome Editing 5 National and International Governance of Heritable Human Genome Editing References Appendix A: Information Sources and Methods Appendix B: Commissioner Biographies Appendix C: Glossary Appendix D: Acronyms and Abbreviations Acknowledgment of Reviewers Full Product DetailsAuthor: The Royal Society , National Academy of Sciences , National Academy of Medicine , International Commission on the Clinical Use of Human Germline Genome EditingPublisher: National Academies Press Imprint: National Academies Press ISBN: 9780309671132ISBN 10: 0309671132 Pages: 238 Publication Date: 16 January 2021 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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