Overview

Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT), Volume 201 provides the latest information on what has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis, and many immune neuropathies. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to new insights on the pathological mechanisms underlying CNS autoimmunity, hence this volume summarizes that research.

Full Product Details

Author:   Matilde Inglese (DINOGMI, University of Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy) ,  Giovanni L. Mancardi (Universita di Genova, DINOGMI, Genova, Italy)
Publisher:   Elsevier - Health Sciences Division
Imprint:   Elsevier - Health Sciences Division
ISBN:  

9780323902427

ISBN 10:   0323902421
Pages:   346
Publication Date:   11 September 2024
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In stock  
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Table of Contents

1. Introduction to HSCT for neurologic diseases 2. Modification of T and B cell-associated immuno-pathological mechanisms in multiple sclerosis by disease modifying therapies: achievements and opportunities 3. The hematopoietic niche and the autoreactive memory in autoimmune disorders 4. The preclinical data and immunological rationale for hematopoietic stem cell transplantation in autoimmunity 5. Immune cell reconstitution following autologous hematopoietic stem cell transplantation in multiple sclerosis 6. Immune reconstitution in rheumatic disease patients after autologous hematopoietic stem cell transplantation 7. The role of chemotherapy in hematopoietic stem cell transplantation HSCT for autoimmune disorders: from lymphoablative to myeloablative conditioning protocols 8. The HSCT procedure (I): mobilization, collection, manipulation and cryopreservation of HSC 9. The HSCT procedure (II): conditioning, hemopoietic stem cell infusion, supportive care and monitoring 10. Early and late complications of HSCT 11. Hematopoietic Stem Cell Transplantation for Multiple Sclerosis 12. Hematopoietic stem cell transplantation for neuromyelitis optica spectrum disorder. Can immune tolerance be re-established? 13. Hematopoietic stem cell transplantation (HSCT) for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): Is it CIDP? 14. HSCT for Stiff Person Syndrome and Myasthenia Gravis 15. Autologous hematopoietic stem cell transplantation for pediatric autoimmune neurologic disorders 16. HSCT for systemic autoimmune diseases with neurologic involvement 17. Hematopoetic Stem Cell Therapy and Ex Vivo Gene Therapy for X-linked Adrenoleukodystrophy 18. Economics of Hematopoietic Stem Cell Transplant in immune-mediated neurologic autoimmune diseases 19. The EBMT-ADWP and the CIBMTR 20. Ongoing randomized clinical trials on HSCT in multiple sclerosis

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Author Information

Matilde Inglese is at the University Hospital IRCCS Ospedale Policlinico San Martino Department of Neurology, Genoa, Italy. Giovanni L. Mancardi is at the Universita di Genova, DINOGMI, in Genova, Italy.

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