Overview

Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.

Full Product Details

Author:   Ariel Ruiz i Altaba
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2006 ed.
Dimensions:   Width: 15.50cm , Height: 1.30cm , Length: 23.50cm
Weight:   0.379kg
ISBN:  

9781489989765

ISBN 10:   1489989765
Pages:   228
Publication Date:   04 December 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

How the Hedgehog Outfoxed the Crab.- The Patched Receptor.- Making a Morphogenetic Gradient.- Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signaling.- Mode of PTCH1/Ptch1-Associated Tumor Formation.- Basal Cell Carcinomas, Hedgehog Signaling, and the Ptch1+/- Mouse.- GLI Genes and Their Targets in Epidermal Development and Disease.- Splitting Hairs.- Shh Expression in Pulmonary Injury and Disease.- Human Correlates of GLI3 Function.- From Oligodactyly to Polydactyly.- The Genetics of Indian Hedgehog.- Sonic Hedgehog Signaling in Craniofacial Development.- Important Role of Shh Controlling Gli3 Functions during the Dorsal-Ventral Patterning of the Telencephalon.- Regulation of Early Events in Cell Cycle Progression by Hedgehog Signaling in CNS Development and Tumorigenesis.- Modulating the Hedgehog Pathway in Diseases.- Hedgehog Signaling in Endodermally Derived Tumors.

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