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OverviewHaptoglobin, a plasma glycoprotein, binds free hemoglobin with high affinity and prevents the loss of iron from the body. Hence, haptoglobin plays an important role in protection of haemolytic disease by reducing the oxidative and peroxidative potential at free haemoglobin. The present study is concerned with the distribution of hemoglobin content and haptoglobin variants among the Brahmin, a caste endogamous community, of Solan District, Himachal Pradesh (India). In the present study, most of the peoples have normal hemoglobin content. When male and female are concerned individually, males are more anemic than the females. Hp gene was found to be polymorphic and population deviate from Hardy Weinberg Equilibrium (χ2=10.828, p>0.001) since there are significant differences in the expected and observed frequency distribution of Hp. The HP*2 allele was found with a very high frequency (0.97). This could possibly be due to angiogenic property of Hp2-2 type, lower risk of the HP2-2 phenotype compared to other phenotypes or it could be due to the possible selective advantage of the mutant HP*2 allele. Such high frequency of the mutant HP*2 allele observed needs to be probed into. Full Product DetailsAuthor: Huidrom Suraj Singh , Kallur Nava SaraswathyPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Dimensions: Width: 15.20cm , Height: 0.60cm , Length: 22.90cm Weight: 0.159kg ISBN: 9783659106729ISBN 10: 3659106720 Pages: 100 Publication Date: 27 April 2012 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |