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Author:   Leslie L. Iversen, PhD ,  Susan D. Iversen, PhD ,  Solomon H. Snyder
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1982
Dimensions:   Width: 17.00cm , Height: 2.30cm , Length: 24.40cm
Weight:   0.761kg
ISBN:  

9781461334545

ISBN 10:   1461334543
Pages:   442
Publication Date:   12 December 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 Electrochemical Detection Methods for Monoamine Measurements in Vitro and in Vivo.- 1. Introduction.- 2. Assay of Aromatic Amines by HPLC with Electrochemical Detection.- 3. Faradaic Electrochemistry in the CNS.- Appendix: Instrumentation for Electrochemical Studies.- Liquid Chromatography.- In Vivo Electrochemistry.- Commercial Voltammetric Equipment.- 4. References.- 2 Radioreceptor Assays for Neurotransmitters and Drugs.- 1. Introduction.- 2. Fundamentals of Receptor Binding Assays.- 3. Fundamentals of Radioreceptor Assays.- 4. Applications.- 5. Summary.- 6. References.- 3 Intracellular Recording from Neurons in Brain Slices in Vitro.- 1. Introduction.- 2. Procedures for Preparing and Maintaining Brain Slices.- 3. Intracellular Studies.- 4. Epileptogenesis.- 5. Synaptic Plasticity.- 6. Iontophoresis.- 7. Concluding Remarks.- 8. References.- 4 Capsaicin: A Chemical Probe for Sensory Neuron Mechanisms.- 1. Introduction.- 2. Chemical Analysis of Capsaicin and Related Natural Products.- 3. General Considerations of Capsaicin Administration.- 4. Effects on the Respiratory and Cardiovascular System.- 5. Neuroanatomical Observations.- 6. Neurophysiological Observations.- 7. Effects on Inflammation.- 8. Effects on Thermoregulation.- 9. Effects on the Gastrointestinal Tract.- 10. Noxious Properties and Effects on Nociception.- 11. Biochemical Observations.- 12. Structure-Activity Relationships.- 13. Summary and Perspectives.- 14. References.- 5 Excitatory Amino Acid Neurotoxins.- 1. Introduction.- 2. Pharmacology of Excitatory Amino Acids.- 3. Excitotoxins: Structure-Activity Relations.- 4. Kainic Acid.- 5. Other Excitotoxins.- 6. Practical Applications.- 7. Conclusion.- 8. References.- 6 High-Performance Liquid Chromatography: Purification and Characterization of Neuropeptides.- 1. Introduction.- 2. Equipment.- 3. HPLC Column.- 4. Reverse-Phase HPLC.- 5. Polar and Ion-Exchange Phases.- 6. Exclusion Chromatography.- 7. Strategy.- 8. Neuropeptide Analysis by HPLC.- 9. Neurological Disorders and Pain.- 10. Schizophrenia.- 11. Stimulation of Aldosterone Release.- 12. Future Trends: HPLC-MS.- 13. References.- 7 Localization of Drug and Neurotransmitter Receptors in Brain by Light Microscopic Autoradiography.- 1. Introduction.- 2. Methodology.- 3. Radiohistochemistry of Receptors as a Complement to Neurotransmitter Mapping.- 4. Suggestions about Mechanisms of CNS Drug Action.- 5. Other Uses of Receptor Mapping.- 6. Electron Microscopic Studies.- 7. Summary.- 8. References.- 8 Mapping Functional Alterations in the CNS with 14[C]Deoxyglucose.- 1. Introduction.- 2. General Methodological Considerations.- 3. Metabolic Consequences of Manipulating Central Neurotransmitter Systems.- 4. Glucose Utilization following Neuropharmacological Manipulations.- 5. Perspectives of Metabolic Mapping in Neuropharmacology.- 6. References.

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