Overview

"Perhaps more than any other group of psychotropic drugs, the neuroleptics are a focus for integrating clinical application, neurotransmitter disposition, and pathophysiologic mechanisms of mental illness. Neuroleptic is a term referring to drugs of several chemical classes-phenothiazines, thioxan- thenes, and butyrophenones-which have in common a selective ability to alleviate schizophrenic symptoms. Delay and Deniker derived the word neuroleptic from the Greek meaning ""to grasp the neuron. "" They coined the name because they noted that therapeutic responses to chlorpromazine tended to accompany the onset of neurological, extrapyramidal side effects, which they therefore felt related to the essence of the drug's antischizo- phrenic actions. Subsequent research, particularly relating to neuroleptic effects on dopamine receptors, suggests that both therapeutic and neurologic untoward effects involve dopaminergic mechanisms, explaining their close though not invariant association. The chapter by Davis and Garver summa- rizes clinical facets of neuroleptics, analyzing their apparently specific clinical effects as well as reviewing practical features of drug use. Crane's chapter deals with tardive dyskinesia and other neurological side effects. Fielding and Lal discuss behavioral studies in animals which provide models for assessing the drugs' therapeutic efficacy. Janssen and Van Bever deal with the remarkable structure-activity relationships of the butyrophenones, the most potent and selective neuroleptics which were almost single-handedly devel- oped through the brilliant efforts of Paul Janssen. Shore and Giachetti describe basic and clinical features of reserpine, the neurotransmitter effects of which differ from ."

Full Product Details

Author:   Leslie Iversen
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1978
Dimensions:   Width: 17.00cm , Height: 1.40cm , Length: 24.40cm
Weight:   0.468kg
ISBN:  

9781461340447

ISBN 10:   1461340446
Pages:   250
Publication Date:   12 October 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1 Structure-Activity Relationships of the Butyrophenones and Diphenylbutylpiperidines.- 1. Introduction.- 2. Structure-Activity Relationships.- 3. Pharmacology.- 4. Conclusion.- 5. References.- 2 Biochemical Actions of Neuroleptic Drugs: Focus on the Dopamine Receptor.- 1. Introduction.- 2. Early Biochemical Studies.- 3. Dopamine Metabolism and Neuroleptics.- 4. The Dopamine-Sensitive Adenylate Cyclase.- 5. Labeling the Dopamine Receptor.- 6. References.- 3 Behavioral Actions of Neuroleptics.- 1. Introduction.- 2. Effect on Feeding and Drinking.- 3. Locomotor Activity and Catalepsy.- 4. Antiamphetamine Action.- 5. Avoidance Behavior.- 6. Brain Self-Stimulation.- 7. Aggression.- 8. Narcotic-Withdrawal Syndrome.- 9. Conclusions.- 10. References.- 4 Neuroleptics: Clinical Use in Psychiatry.- 1. Introduction.- 2. The Methodology of Drug Studies.- 3. Efficacy of Antipsychotic Drugs.- 4. Maintenance Treatment with Antipsychotic Medication.- 5. Cost of Medication and Dispensing.- 6. Antipsychotic Drugs and Somatic Therapies.- 7. Drug Combinations.- 8. Drug, Psychological, and Social Treatments.- 9. New Antipsychotic Drugs.- 10. References.- 5 Tardive Dyskinesia and Related Neurologic Disorders.- 1. Historical Background.- 2. Clinical Findings.- 3. Predisposing Factors.- 4. Drug Effects.- 5. Severity and Combinations of Symptoms.- 6. Disability and Complications.- 7. Differential Diagnosis.- 8. Pathophysiology.- 9. Neuropharmacology.- 11. Concluding Remarks.- 12. References.- 6 Reserpine: Basic and Clinical Pharmacology.- 1. Introduction.- 2. Source, History, and Analogs.- 3. Distribution and Metabolism.- 4. Pharmacological Effects in Laboratory Animals.- 5. Clinical Pharmacology.- 6. Biochemical Mechanism of Action.- 7. Interaction of Reserpine with Other Centrally Acting Drugs.- 8. The Reserpine Receptor.- 9. References.- 7 Neurotransmitter Theories of Schizophrenia.- 1. Introduction.- 2. Survey of Neurotransmitter Theories.- 3. General Principles Underlying Neurotransmitter Theories in Psychiatry.- 4. Attention in Schizophrenia and Its Pharmacology.- 5. References.

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