Overview

In the Handbook of Neurotoxicology, Volumes I and II, many leading researchers and clinicians - all acknowledged experts - review in depth the status of research in key areas of current neurotoxicologic interest and examine the latest methodologies for in vivo assessment of a wide spectrum of agents exhibiting neurotoxicologic properties. The first volume of the Handbook focuses on the biological effects of human-made neurotoxins, as well as those of natural origin, which so often provide valuable therapeutics and research reagents. Topics range from anticholinesterase insecticides and pesticides that target ion channels, to such metals as mercury, lead, zinc, and to the polytypic byproducts of combustion and industrial manufacture. The natural toxins discussed include those of microbial origin (microbial, marine, clostridial, and botulilinal neurotoxins), as well as those of animal origin (snake, spider, and scorpion venoms). The second volume concentrates on the biological effects of human-made toxins on the developing nervous system, reviews the neuronal impact of drugs of abuse, and provides state-of-the-art methods for the evaluation of the biological effects of neurotoxicants by both imaging and neurobehavioral assessment.

Full Product Details

Author:   Edward J. Massaro
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2002 ed.
Dimensions:   Width: 17.80cm , Height: 3.20cm , Length: 25.40cm
Weight:   1.626kg
ISBN:  

9780896037953

ISBN 10:   0896037959
Pages:   668
Publication Date:   12 November 2001
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

I. Pesticides.- A. Anticholinesterase Insecticides.- 1 Acute Toxicities of Organophosphates and Carbamates.- 2 Organophosphate-Induced Delayed Neuropathy.- 3 Nonesterase Actions of Anticholinesterase Insecticides.- B. Pesticides that Target Ion Channels.- 4 Agents Affecting Sodium Channels.- 5 Agents Affecting Chloride Channels.- 6 The Neonicotinoid Insecticides.- C. Miscellaneous Pesticides with Action on the Nervous System.- 7 Miscellaneous Pesticides with Action on the Nervous System.- II. Metals.- 8 Molecular Mechanisms of Low-Level Pb2+ Neurotoxicity.- 9 Elucidation of the Zinc-Finger Motif as a Target for Heavy-Metal Perturbations.- 10 Blood-Brain Barrier and Blood-CSF Barrier in Metal-Induced Neurotoxicities.- 11 Manganese in Health and Disease: From Transport to Neurotoxicity.- 12 Aluminum Neurotoxicity.- III. Natural Toxins of Microbial Origin.- 13 Ecology of Microbial Neurotoxins.- 14 Biosynthesis of Important Marine Toxins of Microorganism Origins.- 15 Biological Assay and Detection Methods for Marine “Shellfish” Toxins.- 16 An Overview of Clostridial Neurotoxins.- 17 Molecular Mechanism of Action of Botulinal Neurotoxins and the Synaptic Remodeling They Induce In Vivo at the Skeletal Neuromuscular Junction.- 18 Marine Mammals as Sentinels of Environmental Biotoxins.- 19 The Epidemiology of Human Illnesses Associated with Harmful Algal Blooms.- IV. Natural Toxins of Animal Origin.- 20 Snake Neurotoxins that Interact with Nicotinic Acetylcholine Receptors.- 21 Presynaptic Phospholipase A2 Neurotoxins from Snake Venoms.- 22 Dendrotoxins from Mamba Snakes.- 23 Neurotoxins from Spider Venoms.- 24 Neurotoxins from Scorpion Venoms.- 25 Anthozoan Neurotoxins.- 26 Nemertine Neurotoxins.- 27 Secretagogue Activity of Trachynilysin, a Neurotoxic Protein Isolatedfrom Stonefish (Synanceia trachynis) Venom.- 28 Neurotoxins of Cone Snail Venoms.

Reviews

Both volumes are laid out attractively...and contain much valuable information on the pharmacological aspects of neurotoxicology, as well as state-of-the-art methodology. Le Journal Canadien Des Sciences Neurologies

Both volumes are laid out attractively...and contain much valuable information on the pharmacological aspects of neurotoxicology, as well as state-of-the-art methodology. Le Journal Canadien Des Sciences Neurologies

Both volumes are laid out attractively...and contain much valuable information on the pharmacological aspects of neurotoxicology, as well as state-of-the-art methodology. Le Journal Canadien Des Sciences Neurologies

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