Overview

If you're working on or studying the effects of drug metabolisms, then this reference is for you! Handbook of Metabolic Pathways of Xenobiotics is an essential new reference which presents the metabolic fate of xenobiotics in animals and plants, and shows the metabolic pathways in the environment. Presenting a comprehensive guide to understanding the metabolisms of xenobiotics, the Handbook of Metabolic Pathways of Xenobiotics spans five volumes: Volumes 1-2 are Review Articles and Volumes 3-5 are Compound Articles. Review Articles present detailed reviews on the techniques and methods used to establish in vitro and in vivo metabolic pathways.  Compound Articles are carefully selected lists of key chemicals representing agrochemicals, pharmaceuticals, animal health products and industrial chemicals. An essential addition to every library, this introduction, guide and catalogue presents: Current topics in the metabolism of xenobiotics Topics of both scientific and regulatory importance are covered, including in vitro high throughput metabolism screens, computer-aided metabolism predictions, and advances in bioanalytical techniques. Techniques and methods used in metabolic pathways 29 chapters provide an introduction to the understanding of drug metabolism and detail how to establish in vitro and in vivo metabolic pathways. Biotransformation pathways Presented as a catalogue of short articles covering major pharmaceuticals, agrochemicals, animal health products and industrial chemicals. Each article summarizes the chemical properties and uses, and presents a detailed review of the chemical and metabolic pathways in soil, plants and animals. Over 450 examples of xenobiotics and their fate in animals and plants Each compound includes systematic information about the metabolic pathway of drugs for human and veterinary medicine, agrochemicals and major industrial chemicals. Chemical and biological fate data The Handbook summarises data from scientific literature, patent literature, industrial resources and regulatory agencies, such as the EPA, FDA, EU, WHO and FAO, in a single reference for the first time. An essential reference for everyone working and studying pharmacokinetics and drug metabolism Coverage of the chemical and biological reactivity of molecules and primary sub-structures makes this an ideal reference for students and research scientists. The broad and diverse coverage of chemical and biological fate under different exposure and biological compartments make this a useful resource for regulatory and developmental scientists.

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Dr Philip W. Lee, School of Pharmacy, East China University of Science and Technology, Shanghai, Peoples' Republic of China.Dr. Philip W. Lee has more than 35 years of industrial experience in the field of agrochemical research and development. He is currently Professor at School of Pharmacy, East China University of Science and Technology. He has published more than 40 scientific articles in pesticides and drug metabolism and environmental chemistry. Dr. Lee is a contributing editor for the Volume 1 and 2 of the Metabolic Pathways of Agrochemicals, published by Royal Society of Chemistry (RSC) in 1998 and 1999, and is the Editor-in-Chief of a 2-volume Handbook of Residue Analytical Methods for Agrochemicals, published by Wiley in 2003. He is the editor of Pesticide Chemistry: Crop Protection, Public Health and Environmental Safety, conference proceeding book of the 2006 IUPAC International Pesticide Congress, Kobe, Japan, published by Wiley-VCH, 2007. Hiroyasu Aizawa, Hiro Research Consultancy Inc. (HRCI), Toyko, Japan. Lawrence L. Gan, Biogen Idec, Inc., Cambridge, MA, USA. Chandra C. Prakash, Biogen Idec, Inc., Cambridge, MA, USA. Dafang D. Zhong, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, Peoples' Republic of China. Dr. Hiro Aizawa has been active for more than 20 years in the study of animal drug metabolism. Dr Lawrence Gan and Dr. Chandrah Prakash are active with a long experience in the development of human drugs and the study of human drug metabolism.

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