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OverviewDuring the last few years there has been growing interest in the large family of GTPases structurally related to protooncogene product p21 ras. These proteins share structural similarities but are involved in a large spectrum of biological functions. While members of the ras subfamily regulate cell growth, rho proteins are implicated in the control of cytoskeletal organization in mammalian cells or in bud formation in yeast. Members of the ARF/SAR family are postulated to control vasicle budding, whereas Ypt1/Sec4/rab proteins are thought to regulate vesicle targeting and/or fusion. Owing to their functional divergence, the small GTPases have attracted the attention of many investigators in the fields of structural biology, cell biology, cell growth and differentiation and developmental biology. Numerous studies have contributed important data on the biochemical features, the intracellular focalisation, and in some cases, the function of these proteins. This book contains entries on almost 150 GTPases which have been identified so far, and the search has not yet been exhausted. This large repertoire of information is gathered together in an easy to consult format. This book is meant to provide a catalogue of the information currently at hand to established scientists in the field, as well as to introduce more investigators to their proteins of interest. Full Product DetailsAuthor: Marino Zerial (European Molecular Biology Laboratory, Heidelberg) , Lukas A. Huber (Department of Biochemistry, University of Geneva)Publisher: Oxford University Press Imprint: Oxford University Press Dimensions: Width: 19.00cm , Height: 2.90cm , Length: 24.50cm Weight: 1.112kg ISBN: 9780198599449ISBN 10: 0198599447 Pages: 496 Publication Date: 07 December 1995 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Out of Print Availability: In Print Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock. Table of ContentsReviewsThe breadth and depth of knowledge contained in this guidebook as well as the accessibility of information make it an excellent addition to the other guidebooks in this series. --Journal of the American Chemical Society<br> A thorough survey of the identities and cellular functions of small GTPases and their regulators....Highly recommended. --Quarterly Review of Biology<br> Author InformationTab Content 6Author Website:Countries AvailableAll regions |