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OverviewGlycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate. This volume discusses the role of GAGs in development, health and disease. Full Product DetailsAuthor: Lijuan Zhang (Ocean University of China, Qingdao, China)Publisher: Elsevier Science Publishing Co Inc Imprint: Academic Press Inc Edition: 93rd edition Volume: 93 Dimensions: Width: 15.20cm , Height: 3.60cm , Length: 22.90cm Weight: 0.960kg ISBN: 9780123812827ISBN 10: 0123812828 Pages: 408 Publication Date: 28 October 2010 Audience: College/higher education , Professional and scholarly , Postgraduate, Research & Scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsMice deficient in heparan sulfate N-sulphotransferase-1 Lena Kjellén and Maria Ringvall Mice deficient in heparan sulfate epimerase Jin ping Li Mice deficient in heparan sulfate 3-O-sulfotransferase-1 Nicholas W. Shworak Mice deficient in heparan sulfate 6-O-sulfotransferase-1 Koji Kimata and Hiroko Habuchi Mice deficient in dermatan sulfate Epimerase Marco Maccarana and Anders Malmström The roles of chondroitin-4-sulfotransferase-1 in development and disease Michael Klüppel Conditionally disrupted EXT1 in the embryonic mouse brain. Yu Yamaguchi Endothelial heparan sulfate in inflammation Jeffrey D. Esko and Ding Xu Endothelial heparan sulfate in angiogenesis Jeffrey D. Esko, Mark M. Fuster and Lianchun Wang Hepatocyte heparan sulfate and lipoprotein metabolism Jeffrey D. Esko and Erin Foley Serglycin proteoglycan deletion in mouse platelet Barbara P. Schick GAGs in Amyloidosis Jin ping Li and Xiao Zhang Selectins, Heparins and Tumor Metastasis Lubor Borsig Chondroitin sulfate and Rheumatoid arthritis Lijuan Zhang Adducted thumb-clubfoot syndrome (ACTS) and Loss of dermatan-4-sulfotransferase 1 function Jacques U Baenziger,Thomas Müller, Andreas Janecke and Lijuan Zhang Vascular dermatan sulfate and heparin cofactor II Douglas M. Tollefsen Diverse Functions of Glycosaminoglycans in Infectious Diseases Pyong Woo Park, Rafael Aquino, and Eui Seung Lee Lessons learned from contaminated heparin. 1: Molecular mechanism underlines heparin induced thrombocytopenia and thrombosis. Lijuan Zhang Lessons learne from contaminated heparin. 2: Contact System Activation-induced Thrombin in Unrelated Human Thromboembolic Diseases Lijuan Zhang, Peter Weiser, Yi Qian and Jing PanReviewsPRAISE FOR THE SERIES: Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell. --British Medical Journal PRAISE FOR THE SERIES: Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell. --British Medical Journal Author InformationLijuan Zhang is a Professor of Translational Medicine at Ocean University of China. She completed her doctorates of biochemistry and molecular genetics at University of Alabama at Birmingham in 1995. Before then, she was a Fogarty International Fellow at NIH for three years studying glycan-based cancer biomarkers. She worked as post-doctorate fellow and research associate at both MIT and Harvard Medical School from 1995-2002. She joined the faculty of the Department of Pathology & Immunology at Washington University in St. Louis in 2002 as a tenure-tracked Assistant Professor. Her research had been focused on the biosynthesis, structures, and biological functions of glycans since 1985. Now her work is on translational aspects of glycans as biomarkers and therapeutics. She has over 60 peer reviewed publications. She edited and published a book entitled “Glycosaminoglycans in Development, Health, and Diseases with the contributions of top scientists worldwide in 2010 by Elsevier. Tab Content 6Author Website:Countries AvailableAll regions |
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