Overview

In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the glutamate cascade to determine their roles in various addictive states.

Full Product Details

Author:   Barbara H. Herman ,  Raye Z. Litten ,  P. Sheridan ,  F.F. Weight
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2002 ed.
Dimensions:   Width: 17.80cm , Height: 2.50cm , Length: 25.30cm
Weight:   2.410kg
ISBN:  

9780896038790

ISBN 10:   0896038793
Pages:   440
Publication Date:   22 August 2002
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I. Introduction: Physiology and Pharmacology of Glutamate.- 1 Molecular Pharmacology and Physiology of Glutamate Receptors.- 2 Pharmacology of Glutamate Receptors.- 3 Glutamate and Neurotoxicity.- 4 Maturational Regulation of Glutamate Receptors and Their Role in Neuroplasticity.- 5 Role of the NMDA Receptor in Neuronal Apoptosis and HIV-Associated Dementia.- II. Glutamate: Stimulant Drugs of Abuse (Cocaine, Amphetamine, Methamphetamine).- 6 Role of Glutamate and Nitric Oxide in the Acquisition and Expression of Cocaine-Induced Conditioned Increases in Locomotor Activity.- 7 Interactions of Dopamine, Glutamate, and GABA Systems in Mediating Amphetamine- and Cocaine-Induced Stereotypy and Behavioral Sensitization.- 8 Addiction and Glutamate-Dependent Plasticity.- 9 Glutamate and Dopamine Interactions in the Motive Circuit: Implications for Craving.- 10 Glutamate Cascade from Metabotropic Glutamate Receptors to Gene Expression in Striatal Neurons: Implications for Psychostimulant Dependence and Medication.- 11 Glutamate Neurotransmission in the Course of Cocaine Addiction.- 12 Glutamate and the Self-Administration of Psychomotor-Stimulant Drugs.- 13 Roles of Glutamate, Nitric Oxide, Oxidative Stress, and Apoptosis in the Neurotoxicity of Methamphetamine.- 14 Methamphetamine Toxicity: Roles for Glutamate, Oxidative Processes, and Metabolic Stress.- 15 Nitric Oxide-Dependent Processes in the Action of Psychostimulants.- 16 Effects of Novel NMDA/Glycine-Site Antagonists on the Blockade of Cocaine-Induced Behavioral Toxicity in Mice.- 17 Clinical Studies Using NMDA Receptor Antagonists in Cocaine and Opioid Dependence.- 18 The Role of mGluR5 in the Effects of Cocaine: Implications for Medication Development.- III. Glutamate and Opiate Drugs (Heroin) of Abuse.- 19 Role of theGlutamatergic System in Opioid Tolerance and Dependence: Effects of NMDA Receptor Antagonists.- 20 The Role of NMDA Receptors in Opiate Tolerance, Sensitization, and Physical Dependence: A Review of the Research, A Cellular Model, and Implications for the Treatment of Pain and Addiction.- 21 Modification of Conditioned Reward by N-Methyl-D-aspartate Receptor Antagonists.- 22 Morphine Withdrawal as a State of Glutamate Hyperactivity: The Effects of Glutamate Receptor Subtype Ligands on Morphine Withdrawal Symptoms.- IV. Glutamate and Alcohol Abuse and Alcoholism.- 23 Alcohol Actions on Glutamate Receptors.- 24 Glutamate and Alcohol-Induced Neurotoxicity.- 25 Role of Glutamate in Alcohol Withdrawal Kindling.- 26 Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment.- 27 Mechanism of Action of Acamprosate Focusing on the Glutamatergic System.- 28 The NMDA/Nitric Oxide Synthase Cascade in Opioid Analgesia and Tolerance.- 29 Overview of Clinical Studies for Acamprosate.

Reviews

Illuminating, authoritative, and forward looking, Glutamate and Addiction clarifies for the first time the relationship between glutamatergic systems and addiction investigations of many of today's emerging therapeutics for addictive disorders. - Biomedicine and Pharmacotherapy

"""Illuminating, authoritative, and forward looking, Glutamate and Addiction clarifies for the first time the relationship between glutamatergic systems and addiction investigations of many of today's emerging therapeutics for addictive disorders."" -Biomedicine and Pharmacotherapy"

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