Overview

Giardia is a relatively simple eukaryotic microbe, causing acute and chronic diarrhea which has been used as a model to understand complex biological processes occurring in eukaryotic cells. Further, due to its parasitic lifestyle, Giardia is an excellent system for the study of the mechanisms of adaptation and cell differentiation from the perspectives of molecular and cell biology. This book presents a comprehensive review of the current state of knowledge regarding all aspects of Giardia's biology, including epidemiology, cell and molecular biology, genetics, pathogenesis, diagnostics, and clinical treatment. It was written by internationally renowned authors, the leading researchers in the field including several chapters with techniques and resources available for the study of this microorganism. Questions that need to be addressed to fully understand the molecular mechanisms of the parasite as well as the cause of its pathology are presented. Furthermore, Giardia's biology is compared with that of other parasites in relation to their complexity. This volume is an indispensable resource for researchers working with this parasite. It is a must for libraries and the bookshelves of everyone interested in the biology of parasites and early-branching eukaryotes.

Full Product Details

Author:   Hugo D. Lujan ,  Staffan Svard
Publisher:   Springer Verlag GmbH
Imprint:   Springer Verlag GmbH
Edition:   Softcover reprint of the original 1st ed. 2011
Weight:   1.117kg
ISBN:  

9783709119273

ISBN 10:   3709119278
Pages:   420
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Preface and Introduction.- Section I: Taxonomy and Epidemiology of Giardia.- 1 Taxonomy of Giardia Species.- 2 Epidemiology of Giardiasis in Humans.- 3 Waterborne and Environmentally-Borne Giardiasis.- 4 Giardia in Pets and Farm Animals, and Their Zoonotic Potential.- Section II: Molecular Biology of Giardia.- 5 Genomics of Giardia.- 6 The Glycoproteins of Giardia.- 7 Mass Spectrometric Analysis of Phospholipids and Fatty Acids in Giardia lamblia.- 8 Giardia Metabolism.- Section III: Cellular Biology of Giardia.- 9 The Ultrastructure of Giardia During Growth and Differentiation.- 10 Cell Cycle Regulation and Cell Division in Giardia.- 11 The Giardia Mitosomes.- 12 Signaling Pathways in Giardia lamblia.- 13 Transcription and Recombination in Giardia.- 14 Intracellular Protein Trafficking.- 15 Post-transcriptional Gene Silencing and Translation in Giardia.- 16 Antigenic Variation in Giardia.- Section IV: Pathology, Treatment and Diagnostics of Giardia and the Host Immune Response.- 17 Interaction of Giardia with Host Cells.- 18 Primary Microtubule Structures in Giardia.- 19 Pathophysiological Processes and Clinical Manifestations of Giardiasis.- 20 Immunology of Giardiasis.- 21 Vaccination Against Giardia.- 22 Diagnosis of Human Giardiasis.- Section V: Methods for Giardia Research.- 23 Methods for Giardia Culture, Cryopreservation, Encystation, and Excystation In Vitro.- 24 Synchronization of Giardia.- 25 Methods for Giardia Transfection and Gene Expression.- 26 Biological Resource Centers for Giardia Research.

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Author Information

Dr. Lujan received his Ph.D. in biochemistry from the School of Chemistry, National University of Cordoba, Argentina, in 1991. Until 1996 he performed postdoctoral work in the United States at the National Institute of Allergy and Infectious Diseases, National Institutes of Health. He is a full professor of biochemistry and cell biology in the School of Medicine, Catholic University of Cordoba, Argentina. He also is an independent investigator at the National Council for Science and Technology of Argentina. Dr. Svard received his PhD in Microbiology at Uppsala University, Uppsala, Sweden in 1995. He performed postdoctoral work in United States at UCSD, San Diego followed by six years at the Karolinska Institute, Stockholm, Sweden. Currently he is a professor of Eukaryotic Microbiology at Uppsala University.

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