Overview

Genetic diseases and disorders are common factors in modern pharmacogenomics. The study of emerging factors in epigenomics are significant for effective drug discovery and formulation, as well as for balancing pharmacological and ethical factors in drug development. The goal of drug discovery is to recognize the new molecular formulations impactful in the treatment of genetic diseases. Further exploration of the move from preclinical drug research to the clinical stage may reveal critical transformations to provide effective medicinal products in the market. As precision medicine evolves, genomics-driven drug discovery may also improve patient outcomes while reducing the trial-and-error approach to prescribing medications, assisting with individualized, targeted healthcare. Genomics-Driven Drug Discovery Through Pharmacogenomics explores the integration of genomics into drug discovery and development in the pharmacogenomics field. It offers effective solutions to address challenges of personalized healthcare, ethical dilemmas, and technological considerations involved in drug discovery. This book covers topics such as medical technology, personalized medicine, and drug development, and is a useful resource for medical professionals, healthcare workers, computer engineers, scientists, pharmacologists, academicians, and researchers.

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Arli Aditya Parikesit received his doctoral degree PhD (Informatics) from Computational EvoDevo, Institute of Computer Science, University of Leipzig, Germany in 2012 under the supervision of Prof Dr. Sonja Prohaska. Presently he is holding the position of Vice-Rector (R&D) and Professor in the Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences (i3L), Indonesia. His selected works- Evolutionary Analysis of the Protein Domain Distribution in Eukaryotes: Computing genome-wide Protein Domain Annotation of RefSeq and Gene Prediction. Investigating domain co-occurrences tendency of the Selected Genomes. In Silico Design of Therapeutic and Preventive agents for Virus-based disease. Ongoing Project: Drugs and Vaccines design on Influenza A, Dengue, and HPV. Breast Cancer RNA drug design, COVID-19 Herbal Medicine, and Fish Transcriptomics. Rajesh G. Konnur received her doctoral degree PhD (Biotechnology) from Trinity College Seychelles in 2010. Presently he is holding the position of Director in Eudoxia Research Centre, India. His selected works- Book: Psychology for Graduate Nurses. Book: Text book of Psychiatric Nursing. Book: Clinical Record Book for Mental Health Nursing. Book: Advanced Nursing Practice. Book: Nursing Management. National Conference on Child Psychiatric Nursing. National Conference on Women's Mental Health: Nursing Perceptive. National Conference on drug Abuse. International Conference on Adolescent Mental Health Issues and Problems: Nursing perspectives. National Conference on Geriatric Mental Health Nursing. World Summit on Medical Sciences, Pharmaceutical sciences and Nursing sciences. Saptarshi Mukherjee received her master degree M.Tech. (Bioinformatic) and M.Sc. (Computer Science and Engineering) from Maulana Abul Kalam Azad University of Technology, West Bengal, India. Presently he is holding the position of Research Administrator in GoldSmith Institute of Advanced Research (GIAR), India. His selected works- Precision Medicine in Lung Cancer Treatment. Precision Medicine in Acute myeloid leukemia. Biologically Synthesized Silver Nanoparticles: Characterization, Antimicrobial Efficacy, And Mechanistic Insights Using Leaf Extract. AI Integrated predictive inventory management system for manufacturing supply chains. Neonatal Diabetes Mellitus: Unravelling the clinical, genetic, and nutritional dimensions for enhanced management. Diabetes Mellitus and its role in the devolopment and progression of atrial fibrillation -A review and Recommendations. Computational Analysis for Dementia Drug Target Identification and Optimization. NGS Analysis Approach for Neurodegenerative Disease with Biopython. Review on Identification and distribution of heat shock proteins in wheat genome. Bacteria with the correct plasmid are used to make more plasmid DNA or, in some cases, induced to express the gene and make protein. DNA cloning is a molecular biology technique that makes many identical copies of a piece of DNA, such as a gene. In a typical cloning experiment, a target gene is inserted into a circular piece of DNA called a plasmid. The plasmid is introduced into bacteria via a process called transformation, and bacteria carrying the plasmid are selected using antibiotics. Silver Nano Particles on antimicrobial plant and finding their physicochemical properties of the antimicrobial plant. Medical Laboratory Technologists perform analyses by preparing slides of human tissues and other specimens using lab equipment. Genetic mutations has led to various rare and prevalent neurological diseases. Parkinson’s disease is a neurodegenerative disorder with a heterogeneous genetic etiology. An early and accurate molecular diagnosis are very much important for neurodegenerative patients to undergo proper therapeutic regimens. The next-generation sequencing (NGS) method is used for examining millions of sequences at a time. Finally, we discuss the NGS challenges and opportunities in neurodegenerative diseases.

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