Overview

Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the “junk” DNA since it does not code for any “useful” protein product. Over the last years this notion changed significantly as scientists discovered that a large part of this DNA contains various genomic elements that have important roles in cell physiology. Genomic elements such as non-coding RNAs, transposons, splicing RNAs, DNA repeats and others were shown to play a significant role in regulating gene expression. In addition, all these elements were implicated to contribute in the pathogenesis or progression of various human diseases. In this book, the editor will attempt to describe all these genomic elements that constitute the junk DNA of the genome. For every genomic element, the physiologic role in the organism, its role in evolution and any possible involvement in human diseases will be discussed. Additionally, interaction between these elements in normal or pathologic condition will be discussed. Since a large amount of new knowledge is generated daily in regards to these genomic elements, this book will attempt to combine all the information in a single publication that can serve as a reference for future studies. The first part will discuss RNA elements such as microRNAs, long non-coding RNAs, piRNAs and splicing RNAs. The second part of the book will deal with transposons, retrotransposons and DNA transposons. Finally the third part of the book will discuss DNA elements that include DNA repeats, conserved non-coding sequences, distal genomic elements, introns, pseudogenes, CpG islands and telomeres. For miRNAs and CNVs a separate chapter will be dedicated to their role in human diseases since an extensive amount of information exists about these two elements.

Full Product Details

Author:   Kyriacos Felekkis ,  Konstantinos Voskarides
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2015
Weight:   5.575kg
ISBN:  

9781493943654

ISBN 10:   1493943650
Pages:   315
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

MicroRNAs' function and role in evolution.- MicroRNAs and disease.- piRNAs: Transposon silencing and germ line development.-Long non-coding cRNAs.- Unveiling transposable elements function to enrich knowledge for human physiology and disease pathogenesis.- Copy number variation in human health, disease and evolution.- Mini- and micro-satellite markers in health, disease and evolution.- Intron biology, focusing on group II introns, the ancestors of spliceosomal introns.- Centromeres in health, disease and evolution.- Structure and functions of telomeres in organismal homeostasis and disease.- Proximal regulatory elements with emphasis on CpG rich regions.- Genomic analysis through high-throughput sequencing.

Reviews

This is the first time I have seen a volume on genomics from the island of Cyprus. ... The chapters are well written, are of high quality, and the references cited reflect an intimate knowledge of current literature. ... This is a useful source for an introduction to the noncoding regions of the human genome. (Krishna Dronamraju, The Quarterly Review of Biology, Vol. 92 (2), June, 2017)

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