Overview

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and graduate students with a molecular biology and genetics background, researchers and practitioners, especially in cancer biology, will also appreciate the book as a reference.

Full Product Details

Author:   James Haber
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 21.00cm , Height: 1.30cm , Length: 28.00cm
Weight:   0.770kg
ISBN:  

9780815344858

ISBN 10:   0815344856
Pages:   416
Publication Date:   16 December 2013
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Replaced By:   9780367174965
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Chapter 1. Restarting DNA Replication by Recombination Chapter 2. Double-strand Break Repair Pathways Chapter 3. RecA/Rad51 and the Search for Homology Chapter 4. Preparation of the RecA/Rad51 Filament Chapter 5. Single-Strand Annealing Chapter 6. Gene Conversion Chapter 7. In vivo Biochemistry: Recombination in Yeast Chapter 8. Break-induced Replication Chapter 9. Sister Chromatid Repair Chapter 10. Gene Targeting Chapter 11. Site-specific Recombination Chapter 12. Cytology and Genetics of Meiosis Chapter 13. Molecular Events During Meiotic Recombination Chapter 14. Holliday Junction Resolvases and Crossing-over Chapter 15. Nonhomologous End-joining Chapter 16. DNA Damage Checkpoints and Genome Instability

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Author Information

James Haber is at Brandeis University, Biology Deptartment, USA.

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