Overview

This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions. Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemicaland biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.

Full Product Details

Author:   Kursad Turksen
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2016
Dimensions:   Width: 15.50cm , Height: 1.00cm , Length: 23.50cm
Weight:   0.454kg
ISBN:  

9783319816876

ISBN 10:   331981687
Pages:   166
Publication Date:   12 June 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Genome Editing with Targetable Nucleases.- CRISPR/Cas9 Approaches to Investigate the Non-coding Genome.- At the Conflux of Human Genome Engineering and Induced Pluripotency.- CRISPR/Cas9 and the Paradigm Shift in Mouse Genome Manipulation Technologies.- Genome Editing Technology in CRISPR/Cas System: How to Increase Knock-in Efficiency in Mouse Zygotes.- Developments in the Generation of Reporter Stem Cells.- Current Status of Genome Editing in Cardiovascular Medicine.- Using CRISPR-Cas9 Genome Editing to Enhance Cell Based Therapies for the Treatment of Diabetes Mellitus.- Genome Editing in the Retina: a Case Study in CRISPR for a Patient-Specific Autosomal Dominant Retinitis Pigmentosa Model.- Index.

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Author Information

Kursad Turksen received his Ph.D. from the University of Toronto in Toronto, Canada in the area of osteoprogenitor biology and cell selection methodologies. He completed his postdoctoral training at the Howard Hughes Medical Institute, University of Chicago, in Chicago, Illinois, studying epidermal biology through use of genetically-altered mouse models. He joined the Ottawa Hospital Research Institute in Ottawa, Canada [previously known as the Loeb Research Institute] where he rose to the position of Senior Scientist in the Division of Regenerative Medicine. His research interests focus on stem cell biology, with a particular interest in the Claudin family of tight junction proteins and their role in epidermal lineage commitment and progression during development in health and disease. Dr. Turksen is currently Editor in Chief of the Springer journal Stem Cell Reviews and Reports in addition to serving as series editor for the Springer series Stem Cell Biology and Regenerative Medicine.

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