Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine

Author:   Henry H. Heng (Professor, Center for Molecular Medicine and Genetics, Pathology Department, Wayne State University School of Medicine, Wayne State University, Detroit, MI, USA)
Publisher:   Elsevier Science Publishing Co Inc
ISBN:  

9780128136355


Pages:   556
Publication Date:   29 May 2019
Replaced By:   9780443154287
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine


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Author:   Henry H. Heng (Professor, Center for Molecular Medicine and Genetics, Pathology Department, Wayne State University School of Medicine, Wayne State University, Detroit, MI, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.880kg
ISBN:  

9780128136355


ISBN 10:   0128136359
Pages:   556
Publication Date:   29 May 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Replaced By:   9780443154287
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

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Dr. Henry H. Heng has coauthored over 200 publications and serves on the editorial boards of seven international, peer-reviewed journals. Using single-cell analysis of in vitro and in vivo models, Dr. Heng’s group has illustrated the evolutionary dynamics of cancer progression by directly observing evolution in action. Such experiments revealed that cancer evolution involves two phases: punctuated genome alteration-mediated macroevolution (which creates a new system), followed by stepwise gene and epigenetic-mediated microevolution (which leads to population growth). By applying this concept to organismal evolution, he discovered that the main function of sex is to reduce genetic diversity at the genome level in order to preserve genome-defined species identity information. Heng introduced the Genome Architecture Theory, a new genome-based conceptual framework of genomics and evolution.

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