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Full Product Details

Author:   Daniel Fairbanks (Brigham Young University) ,  W. Ralph Andersen (Brigham Young University, Emeritus)
Publisher:   Cengage Learning, Inc
Imprint:   Brooks/Cole
Dimensions:   Width: 21.50cm , Height: 3.30cm , Length: 27.60cm
Weight:   1.907kg
ISBN:  

9780534252724

ISBN 10:   0534252729
Pages:   848
Publication Date:   08 January 1999
Audience:   College/higher education ,  General/trade ,  Undergraduate ,  General
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

1. INTRODUCTION Genetics in Human Society / The Universality of Genetic Principles / Model Organisms / Organizing the Study of Genetics / The Concept of the Gene / Genetic Analysis PART I: MOLECULAR FOUNDATIONS OF GENETICS 2. DNA STRUCTURE AND REPLICATION The Genetic Material / Nucleic Acid Structure / Semiconservative DNA Replication / The Process of DNA Replication / Replication of Entire DNA Molecules 3. TRANSCRIPTION AND RNA PROCESSING The Central Dogma / Overview of Transcription and RNA Processing in Prokaryotes and Eukaryotes / Initiation of Transcription / Elongation / Termination / Transcription of rRNAs and tRNAs / mRNA Processing / Processing of rRNAs and tRNAs 4. TRANSLATION AND PROTEIN FUNCTION Amino Acids and Polypeptides / The Genetic Code / Ribosomes, the Sites of Translation / The Role of tRNA / Deciphering the Genetic Code / Initiation of Translation / Elongation / Termination / Protein Structure and Function 5. MUTATION Types of Mutations / Spontaneous Mutation / Induced Mutations / DNA Repair Mechanisms 6. AN INTEGRATED VIEW OF GENE EXPRESSION The Anatomy of a Gene and Its Expression / The Human �-Globin Gene / Enzymes, Biochemical Pathways, and Mutation PART II: GENETICS OF CELLS 7. BACTERIAL GENETICS Bacterial Culture / Structure of Bacterial Chromosomes / DNA Transfer and Recombination / Transformation / Conjugation / Phage Life Cycles / Transduction / Genome Sequencing 8. REGULATION OF GENE EXPRESSION The lac Operon / Mutations in the lac Operon / The trp Operon / Regulation of Lysis and Lysogeny / Transcriptional Gene Regulation in the Eukaryotes / Gene Regulation Beyond Transcription 9. RECOMBINANT DNA AND MOLECULAR ANALYSIS Recombinant DNA / Plasmid Cloning Vectors / Vectors for Cloning Large DNA Inserts / Cloning Strategies / Expression Vectors / The Polymerase Chain Reaction (PCR) / Gel Electrophoresis / DNA, RNA and Protein Blotting / DNA Sequencing 10. EUKARYOTIC GENOME ORGANIZATION Repetitive and Nonrepetitive DNA / Eukaryotic DNA Packaging / The Eukaryotic Chromosome / Gene Organization in Chromosomes / Whole Genome Organization 11. MITOSIS, MEIOSIS, AND LIFE CYCLES The Cell Cycle and Mitosis / Meiosis / A Closer Look at Prophase I / Life Cycles PART III: GENETICS AND ORGANISMS 12. MENDELIAN GENETICS Mendel''''s Experiments / The Molecular Basis of Dominance / The Cellular Basis for Segregation / The Cellular Basis of Independent Assortment / Mendelian Inheritance in Humans / Mendelian Genetics and Probability / About Mendel 13. VARIATIONS ON MENDEL''''S THEME Multiple Alleles and Dominance Relations / Epistasis / Penetrance and Expressivity / DNA Markers in Genetic Analysis 14. SEX DETERMINATION AND SEX-RELATED INHERITANCE Promotion of Cross-Fertilization / Sex Determination / Heteromorphic Chromosomes and Sex Determination / Sex-Linked Inheritance / Dosage Compensation / Sex-Influenced and Sex-Limited Traits 15. CHROMOSOME MAPPING The Discovery of Linkage and Crossing-Over / Two-Factor Linkage Analysis / Map Distance Correction / Three-Factor Linkage Analysis / Multifactor Chromosome Mapping / Genetic Mapping in Humans / Physical Chromosome Mapping / Practical Applications of Chromosome Mapping 16. GENETIC FINE STRUCTURE Tetrad Analysis / Unordered Tetrad Analysis / Gene Conversion and the Mechanism of Crossing-Over / Intragenic Recombination / Complementation / Fine-Structure Mapping / Mitotic Crossing-Over 17. ALTERATIONS IN CHROMOSOME NUMBER AND STRUCTURE Aneuploidy / Polyploidy / Alterations of Chromosome Structure / Chromosome Alterations in Humans 18. EXTRANUCLEAR INHERITANCE The Origins and Cellular Functions of Mitochondria and Plastids / Organellar Genomes / Mitochondrial Inheritance / Mitochondrial DNA and Genetic Disorders in Humans / Plastid Inheritance / Other Types of Extranuclear Inheritance / Correctly Recognizing Extranuclear Inheritance PART IV: GENETICS OF POPULATIONS 19. POPULATION GENETICS Hardy-Weinberg Equilibrium / Genetic Change in Populations / Mutation / Migration / Non-Random Mating / Selection / Random Genetic Drift 20. QUANTITATIVE GENETICS Statistical Descriptions of Metric Characters / Additive Gene Action and Continuous Variation / Heterosis and Inbreeding / Depression / Environmental Variation / Broad-Sense Heritability / Narrow-Sense Heritability and Selection / Limits on Selection 21. EVOLUTIONARY GENETICS Speciation / Molecular Evolution / Maintenance of Genetic Diversity / Phylogenetic Analysis PART V: GENE EXPRESSION AND THE ORGANISM 22. TRANSPOSABLE ELEMENTS Eukaryotic Transposons / Retrotransposons and Retroposons / Prokaryotic Transposons / Using Transposable Elements in Research 23. DEVELOPMENTAL GENETICS Differentiation and Totipotency / Genetic Control of Development in Caenorhabditis elegans / Genetic Control of Development in Drosophila melanogaster / Comparison of Mammalian and Drosophila Development Genetics / Plant Developmental Genetics / Comparison of Plant and Animal Developmental Genetics 24. GENES AND CANCER Genetic Control of the Cell Cycle / The Molecular Basis of Cancer / Examples of Genes That Influence Cancer / The Etiology of Cancer / Cancer Prevention, Detection, and Treatment 25. GENES AND IMMUNITY Immune Responses / Antibody Structure / Antibody Genes / Cell-Mediated Immunity Genes / Immune System Malfunction / Antibodies as Tools in Genetic Research PART VI: APPLICATIONS OF GENETICS 26. GENETICS IN MEDICINE AND FORENSICS The Human Genome Initiative / Genetic Testing / DNA Fingerprinting / Genetic Pharmacology / Human Gene Therapy / Clinical Genetics 27. GENETICS IN AGRICULTURE AND INDUSTRY Genetic Diversity / Plant Breeding / Plant Biotechnology / Animal Breeding and Biotechnology / Applications of Genetics in Industry 28. LEGAL AND ETHICAL ISSUES IN GENETICS Eugenics / Genetic Testing and Screening / Legal Protection and Intellectual Property Rights in Genetics / Recombinant DNA and Safety / Genetics and Science Education / SOLUTIONS TO SELECTED PROBLEMS / GLOSSARY / INDEX

Reviews

1. INTRODUCTION Genetics in Human Society / The Universality of Genetic Principles / Model Organisms / Organizing the Study of Genetics / The Concept of the Gene / Genetic Analysis PART I: MOLECULAR FOUNDATIONS OF GENETICS 2. DNA STRUCTURE AND REPLICATION The Genetic Material / Nucleic Acid Structure / Semiconservative DNA Replication / The Process of DNA Replication / Replication of Entire DNA Molecules 3. TRANSCRIPTION AND RNA PROCESSING The Central Dogma / Overview of Transcription and RNA Processing in Prokaryotes and Eukaryotes / Initiation of Transcription / Elongation / Termination / Transcription of rRNAs and tRNAs / mRNA Processing / Processing of rRNAs and tRNAs 4. TRANSLATION AND PROTEIN FUNCTION Amino Acids and Polypeptides / The Genetic Code / Ribosomes, the Sites of Translation / The Role of tRNA / Deciphering the Genetic Code / Initiation of Translation / Elongation / Termination / Protein Structure and Function 5. MUTATION Types of Mutations / Spontaneous Mutation / Induced Mutations / DNA Repair Mechanisms 6. AN INTEGRATED VIEW OF GENE EXPRESSION The Anatomy of a Gene and Its Expression / The Human ss-Globin Gene / Enzymes, Biochemical Pathways, and Mutation PART II: GENETICS OF CELLS 7. BACTERIAL GENETICS Bacterial Culture / Structure of Bacterial Chromosomes / DNA Transfer and Recombination / Transformation / Conjugation / Phage Life Cycles / Transduction / Genome Sequencing 8. REGULATION OF GENE EXPRESSION The lac Operon / Mutations in the lac Operon / The trp Operon / Regulation of Lysis and Lysogeny / Transcriptional Gene Regulation in the Eukaryotes / Gene Regulation Beyond Transcription 9. RECOMBINANT DNA AND MOLECULAR ANALYSIS Recombinant DNA / Plasmid Cloning Vectors / Vectors for Cloning Large DNA Inserts / Cloning Strategies / Expression Vectors / The Polymerase Chain Reaction (PCR) / Gel Electrophoresis / DNA, RNA and Protein Blotting / DNA Sequencing 10. EUKARYOTIC GENOME ORGANIZATION Repetitive and Nonrepetitive DNA / Eukaryotic DNA Packaging / The Eukaryotic Chromosome / Gene Organization in Chromosomes / Whole Genome Organization 11. MITOSIS, MEIOSIS, AND LIFE CYCLES The Cell Cycle and Mitosis / Meiosis / A Closer Look at Prophase I / Life Cycles PART III: GENETICS AND ORGANISMS 12. MENDELIAN GENETICS Mendel's Experiments / The Molecular Basis of Dominance / The Cellular Basis for Segregation / The Cellular Basis of Independent Assortment / Mendelian Inheritance in Humans / Mendelian Genetics and Probability / About Mendel 13. VARIATIONS ON MENDEL'S THEME Multiple Alleles and Dominance Relations / Epistasis / Penetrance and Expressivity / DNA Markers in Genetic Analysis 14. SEX DETERMINATION AND SEX-RELATED INHERITANCE Promotion of Cross-Fertilization / Sex Determination / Heteromorphic Chromosomes and Sex Determination / Sex-Linked Inheritance / Dosage Compensation / Sex-Influenced and Sex-Limited Traits 15. CHROMOSOME MAPPING The Discovery of Linkage and Crossing-Over / Two-Factor Linkage Analysis / Map Distance Correction / Three-Factor Linkage Analysis / Multifactor Chromosome Mapping / Genetic Mapping in Humans / Physical Chromosome Mapping / Practical Applications of Chromosome Mapping 16. GENETIC FINE STRUCTURE Tetrad Analysis / Unordered Tetrad Analysis / Gene Conversion and the Mechanism of Crossing-Over / Intragenic Recombination / Complementation / Fine-Structure Mapping / Mitotic Crossing-Over 17. ALTERATIONS IN CHROMOSOME NUMBER AND STRUCTURE Aneuploidy / Polyploidy / Alterations of Chromosome Structure / Chromosome Alterations in Humans 18. EXTRANUCLEAR INHERITANCE The Origins and Cellular Functions of Mitochondria and Plastids / Organellar Genomes / Mitochondrial Inheritance / Mitochondrial DNA and Genetic Disorders in Humans / Plastid Inheritance / Other Types of Extranuclear Inheritance / Correctly Recognizing Extranuclear Inheritance PART IV: GENETICS OF POPULATIONS 19. POPULATION GENETICS Hardy-Weinberg Equilibrium / Genetic Change in Populations / Mutation / Migration / Non-Random Mating / Selection / Random Genetic Drift 20. QUANTITATIVE GENETICS Statistical Descriptions of Metric Characters / Additive Gene Action and Continuous Variation / Heterosis and Inbreeding / Depression / Environmental Variation / Broad-Sense Heritability / Narrow-Sense Heritability and Selection / Limits on Selection 21. EVOLUTIONARY GENETICS Speciation / Molecular Evolution / Maintenance of Genetic Diversity / Phylogenetic Analysis PART V: GENE EXPRESSION AND THE ORGANISM 22. TRANSPOSABLE ELEMENTS Eukaryotic Transposons / Retrotransposons and Retroposons / Prokaryotic Transposons / Using Transposable Elements in Research 23. DEVELOPMENTAL GENETICS Differentiation and Totipotency / Genetic Control of Development in Caenorhabditis elegans / Genetic Control of Development in Drosophila melanogaster / Comparison of Mammalian and Drosophila Development Genetics / Plant Developmental Genetics / Comparison of Plant and Animal Developmental Genetics 24. GENES AND CANCER Genetic Control of the Cell Cycle / The Molecular Basis of Cancer / Examples of Genes That Influence Cancer / The Etiology of Cancer / Cancer Prevention, Detection, and Treatment 25. GENES AND IMMUNITY Immune Responses / Antibody Structure / Antibody Genes / Cell-Mediated Immunity Genes / Immune System Malfunction / Antibodies as Tools in Genetic Research PART VI: APPLICATIONS OF GENETICS 26. GENETICS IN MEDICINE AND FORENSICS The Human Genome Initiative / Genetic Testing / DNA Fingerprinting / Genetic Pharmacology / Human Gene Therapy / Clinical Genetics 27. GENETICS IN AGRICULTURE AND INDUSTRY Genetic Diversity / Plant Breeding / Plant Biotechnology / Animal Breeding and Biotechnology / Applications of Genetics in Industry 28. LEGAL AND ETHICAL ISSUES IN GENETICS Eugenics / Genetic Testing and Screening / Legal Protection and Intellectual Property Rights in Genetics / Recombinant DNA and Safety / Genetics and Science Education / SOLUTIONS TO SELECTED PROBLEMS / GLOSSARY / INDEX

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