Overview

Profound mortality rates, due to cardiovascular disease, are a worldwide problem. Cardiovascular disease results from complications of a silent and chronic arterial disease: atherosclerosis. The challenge for the practitioner is adapting diagnostic and therapeutic responses to prevent this common and complex disease. Dyslipidemia, are disorders of the metabolism of soluble transporters of lipids in extracellular spaces of the human body (including blood), called lipoproteins. They are major cardiovascular risk factors, causally related with atherosclerosis and are themselves multifactorial diseases, resulting from interactions between genetic and environmental factors. The study of genetic factors has recently taken a new path with the study of DNA as an experimental object. More than fifty genes of lipoprotein metabolism have been identified in both their physiological actions and their contribution to the pathogenesis of human dyslipidemia. The diversity of observations has refined our current knowledge of the control of lipid metabolism and energy homeostasis in living organisms beyond the limits of the cardiovascular system (e.g., brain, immune system, and development). These studies have given way to a shake-up of former phenotypic classifications, distinguishing new entities, defining targeted therapeutic strategies, providing a basis for different patterns of disease distribution in human populations.

Full Product Details

Author:   Pascale Benlian
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2001
Volume:   7
Dimensions:   Width: 15.50cm , Height: 1.70cm , Length: 23.50cm
Weight:   0.510kg
ISBN:  

9781461355939

ISBN 10:   1461355931
Pages:   315
Publication Date:   05 November 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

I- The Metabolism of Lipoproteins.- 1.1- Historical Landmarks.- 1.2- Lipids are essential components for living cells.- 1.3- Lipoproteins: soluble carriers of lipids in extracellular spaces.- 1.4- The Metabolism of Lipoproteins.- 1.5- Lipids and Atherosclerosis: The Causal Link.- 1.6- Heterogeneity of Dyslipidemia.- II- Genes of Lipoprotein Metabolism.- 2.1- Genes of the endogenous pathway.- 2.2- Genes controlling Triglyceride-rich lipoprotein metabolism.- 2.3- Genes of the Reverse Pathway of lipoprotein metabolism.- 2.4- Other Regulatory Pathways of Lipoprotein Metabolism.- III- The Genetic Basis of Dyslipidemias.- 3.1- The Genetic Architecture of Lipoprotein Metabolism.- 3.2- The Candidate Gene Approach.- 3.3- Novel Genes, Novel Approaches.- Conclusion.- References.

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