|
|
|||
|
||||
OverviewEstrogen has a number of important beneficial effects in the cardiovascular system. We hypothesized that genetic variants in the estrogen receptor alpha (ERalpha) gene may cause variable sensitivity to the hormone and influence an individual's risk of cardiovascular disease, along with other estrogen-sensitive phenotypes. This work explores the role of ERalpha in the mediation of the atheroprotective effects of estrogen and identifies regulatory regions in the ERalpha gene important in cardiovascular tissue. It identifies novel genetic variants in these regions and examines their effect on expression of the receptor in vitro, and their association with estrogen sensitive phenotypes in different study populations. The identification of genetic variations associated with altered estrogen response is of potential public health importance. Insights may be gained into the pathogenesis of cardiovascular as well as other estrogen sensitive diseases contributing to the development and application of newer therapies for these disorders. Full Product DetailsAuthor: Gemma FigtreePublisher: VDM Verlag Dr. Muller Aktiengesellschaft & Co. KG Imprint: VDM Verlag Dr. Muller Aktiengesellschaft & Co. KG Dimensions: Width: 15.20cm , Height: 1.30cm , Length: 22.90cm Weight: 0.347kg ISBN: 9783639155556ISBN 10: 3639155556 Pages: 232 Publication Date: 05 June 2009 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In Print This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |