Overview

Genetic Regulation of Immune Response Pathways, Volume 115 in the Advances in Genetics series, highlights new advances in the field, with this new volume presenting comprehensive chapters on a variety of timely topics. Chapters explore the genetic regulation of immune cells upon activation, IFN response regulation during viral infections, and the role of noncoding RNAs—including lncRNAs and ncRNAs—in immune regulation and inflammation. Additional sections examine the JAK-STAT signaling pathway in inflammatory and autoimmune diseases as a potential therapeutic target, long noncoding RNAs as key regulators of autoimmunity, and the importance of appropriate cytokine expression in maintaining immune response homeostasis. Together, these contributions provide valuable insights into the molecular and genetic mechanisms underlying immune-mediated processes.

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Ainara Castellanos-Rubio obtained her PhD on Genetics from the University of the Basque Country (Spain) in 2010. During her PhD, she studied gene expression alterations and genetic polymorphisms associated to Celiac Disease. She did a short term research stay in the University of Tampere (Finland) under the supervision of Dr. Marku Makki and Dr. Katri Lindfors where she used three dimensional cell cultures to describe different pathways involved in Celiac Disease development. On 2011 she joined the Laboratory of Dr. Sankar Ghosh in Columbia University (NY, USA) where she carried out her postdoctoral studies. During her postdoctoral training, she studied the implication of long noncoding RNAs (lncRNAs) in the immune and inflammatory response and she discovered and functionally characterized a novel lncRNA involved in the susceptibility to Celiac Disease. Dr. Castellanos-Rubio is an Ikerbasque Associate in the University of the Basque Country, where she leads her own group. She is interested in the involvement of noncoding RNAs in the pathogenesis of autoimmune and inflammatory diseases and studies the influence of disease associated SNPs in the functional disturbance of these RNAs. More recently, she has become interested on the epitranscriptomic alterations involved in different aspects of RNA regulation and her group studies how SNPs and environmental factors can alter these epitranscriptomic signals influencing the inflammatory response that finally evolves in disease development.

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