Overview

"This is the latest edition of the core text for courses in molecular biology, genetics, cell biology, and related disciplines. ""Genes V"" provides more introductory material than earlier editions. The contents have been thoroughly revised, reflecting new knowledge and advances. A new section on cell biology integrates material scattered throughout previous editions with the latest developments. The whole book has a greater coherence and more logical structure than ever before. This is reflected by a design which should help to illustrate major points and summarize large amounts of work. People who should find this book interesting include undergraduates in the second, third or fourth years (and sometimes even the first year) of a degree course in molecular biology, biochemistry, genetics, microbiology, virology, cell biology, or preclinical medicine. Research students and scientists who need a thoroughly up-to-date, well-integrated, and authoritative account of the science which may not be their original discipline but has a major impact on their work and that of their competitors should also find this book of interest."

Full Product Details

Author:   Benjamin Lewin
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Edition:   New edition
Dimensions:   Width: 21.00cm , Height: 5.20cm , Length: 27.00cm
Weight:   3.292kg
ISBN:  

9780198542872

ISBN 10:   0198542879
Pages:   1296
Publication Date:   01 January 1994
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   To order  
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Table of Contents

Cells as macromolecular assemblies; Cells obey the laws of physics and chemistry; Cells are organized into compartments. Part 1 DNA as a store of information: Genes are mutable units; DNA is the genetic material; The topology of nucleic acids; Isolating the gene. Part 2 Translation: expressing genes as proteins; The assembly line for protein synthesis; Transfer RNA is the translational adaptor; Ribosomes provide a translation factory; Messenger RNA is the template. Part 3 Constructing the cell: The apparatus for protein localization; Receptors and signal transduction: channels and ion uptake; Cell cycle and growth regulation. Part 4 Control of prokaryotic gene expression: Control at initiation: RNA polymerase-promoter interactions; A panoply of operons - the lactose paradigm and others; Control by RNA structure - termination and antitermination; Phage strategies - lytic cascades and lysogenic repression. Part 5 Perpetuation of DNA: The replicon - unit of replication; Primosomes and replisomes - the apparatus for DNA replication; Systems that safeguard DNA. Part 6 Organization of the eukaryotic genome: The extraordinary power of DNA technology; Genome size and genetic content; The eukaryotic gene - conserved exons and unique introns; Gene numbers - repetition and redundancy; Genomes sequestered in organelles; Organization of simple sequence DNA; The genome is packaged into chromosomes; Chromosomes consist of nucleosomes. Part 7 Eukaryotic transcription and RNA processing: Building the transcription complex - promoters, factors, and RNA polymerases; Regulation of transcription - factors that activate the basal apparatus; The apparatus for nuclear splicing; RNA as catalyst - changing the informational content of RNA. Part 8 The dynamic genome: DNA in flux; Recombination of DNA; Transposons that mobilize via DNA; Retroviruses and retroposons; Rearrangement and amplification in the genome. Part 9 Genes in development; Generation of immune diversity by gene reorganization; Gene regulation in development - gradients and cascades; Oncogenes - gene expression and cancer; Epilogue.

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Author Information

Benjamin Lewin took his undergraduate and postgraduate degrees from Cambridge (England). He was then editor of Nature New Biology and a visiting fellow at the National Institutes for Health. He has been editor of Cell, the premier journal in the field, since 1974. He has unique access to the very best of current research results and thinking.

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