Overview

This book is a collection of preclinical and clinical reports on the application of gene therapy to human disease. The two methods available for delivering therapeutic genes to diseased cells, viral and non-viral vector systems, are detailed and characterized. Several reports describe both approaches currently used in gene therapy: the introduction of a wild-type gene to restore normal gene function in diseased cells, and the use of antisense molecules to hinder abnormal gene expression. Clinical studies detail several different strategies for the treatment of cancer and cardiovascular diseases, using genetic material as therapeutic agents. The regulatory issues governing the use of gene therapy in Europe and the United States are also presented. This book highlights the range of applications and demonstrates the rapid progress being made in the field of gene therapy.

Full Product Details

Author:   Robert E. Sobol ,  Kevin J. Scanlon ,  Eirik Nestaas
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1998
Volume:   27
Dimensions:   Width: 14.80cm , Height: 1.30cm , Length: 21.00cm
Weight:   0.339kg
ISBN:  

9783662035795

ISBN 10:   3662035790
Pages:   242
Publication Date:   03 October 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1 Human Gene Therapy: Future Prospects.- 2 Approaches to the Gene Therapy of Cancer Using Replication-Competent Oncolytic Adenoviruses.- 3 Discovery, Development, and Application of Synthetic Gene Delivery Systems.- 4 Tumor Suppressor Genes.- 5 Oligonucleotide Therapeutics for Human Leukemia.- 6 Ribozymes as Biotherapeutic Tools for the Modulation of Gene Expression.- 7 Cardiovascular Gene Therapy.- 8 Protection of Hematopoietic Progenitor Cells from Chemotherapy Toxicity by Transfer of Drug Resistance Genes.- 9 Pro-drug Gene Therapy for Prostate Cancer.- 10 Hematopoietic Ex Vivo Gene Transfer.- 11 Immunological Approaches for Gene Therapy of Cancer.- 12 Gene Therapy Regulatory Issues in the United States and Europe.- Previous Volumes Published in this Series.

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