Overview

"Gene silencing is a general term describing the epigenetic processes of gene regulation. The term gene silencing is generally used to describe the ""switching off"" of a gene by a mechanism other than genetic modification. This book reviews research in the study of gene silencing including RNA silencing in transgenic plants and mycorrhizal research, gene silencing in the CNS and on the most extensively studied systems to mediate siRNA and shRNA delivery into the brain, siRNA delivery strategies as a therapeutic tool in gene therapy, galectin-3 epigenetics and effective methods for selecting siRNA sequences by using the average silencing probability and a hidden Markov model."

Full Product Details

Author:   Anthony J Catalano
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Dimensions:   Width: 26.00cm , Height: 2.50cm , Length: 18.00cm
Weight:   0.880kg
ISBN:  

9781617282768

ISBN 10:   1617282766
Pages:   374
Publication Date:   26 April 2012
Audience:   College/higher education ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Unknown
Availability:   Awaiting stock  

Table of Contents

Preface; Transgene Silencing in Plants: Mechanisms, Applications & New Perspectives; RNA Silencing in the Ectomycorrhizal Fungus Laccaria bicolor; Gene Silencing as a Promising Strategy to Target CNS & Neurological Disorders; Polymeric Nanoparticles as Efficient siRNA Delivery Systems; Application of Negatively Charged Hydroxyproline-Based DNA Mimics for Gene Silencing; Gene Silencing & the Analysis of Immune Response in Model Insects; RNAI in Plants - Recent Developments & Applications in Agriculture; Silencing of Galectin-3 by Promoter Methylation during Prostate Cancer Progression: A Novel Transcriptional Regulation of Galectin-3 Expression; Effective Methods for Selecting siRNA Sequences by Using the Average Silencing Probability & a Hidden Markov Model; Small RNA-Mediated Gene Silencing for Plant Biotechnology; Post Transcriptional Gene Silencing Methods for Functional Characterization of Abiotic Stress Responsive Genes in Plants; Genome-Wide Identification & Analysis of miRNAs Complementary to Upstream Sequences of mRNA Transcription Start Sites; Gene Silencing: Theory, Techniques & Applications; RNA Interference Mediated by Cell-Penetrating Peptides; Asymmetric RNA Duplexes as Next Generation RNAi Inducers; Index.

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