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OverviewGene silencing is a general term describing epigenetic processes of gene regulation. The term gene silencing is generally used to describe the 'switching off' of a gene by a mechanism other than genetic mutation. That is, a gene which would be expressed (turned on) under normal circumstances, is switched off by machinery in the cell. Genes are regulated at either the transcriptional or post-transcriptional level. Transcriptional gene silencing is the result of histone modifications, creating an environment of heterochromatin around a gene that makes it inaccessible to transcriptional machinery (RNA polymerase, transcription factors, etc.). Post-transcriptional gene silencing is the result of mRNA of a particular gene being destroyed. The destruction of the mRNA prevents translation to form an active gene product (in most cases, a protein). A common mechanism of post-transcriptional gene silencing is RNAi. Both transcriptional and post-transcriptional gene silencing are used to regulate endogenous genes. This book presents the latest research in this important field. Full Product DetailsAuthor: Grace W RedberryPublisher: Nova Science Publishers Inc Imprint: Nova Biomedical Weight: 0.594kg ISBN: 9781594548321ISBN 10: 1594548323 Pages: 201 Publication Date: 01 April 2006 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsPreface; High Frequent Gene Silencing of Hemetopoietic Cell Specific Protein Tyrosinephosphatase SHP1 in Hemetopoietic Cell Malignancies; Age Management Treatments Which Target Silenced Genes; Gene Silencing in Tumours: The Role of the Ras Association Domain Family 1 Gene in Carcinogenesis; Human DNA cis-Elements Protecting the VHL Promoter and CpG Island from Methylation are Functional in the Mouse; Intron-Mediated Gene Silencing; DNA Methylation and Epigenetic Gene Silencing in Breast Cancer; Index.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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