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OverviewDifferential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades. Full Product DetailsAuthor: Surinder K. Batra , Moorthy Palanimuthu Ponnusamy (Department of Biochemistry and Molecular Biology, Nebraska Medical Center, Nebraska, USA)Publisher: Taylor & Francis Ltd Imprint: CRC Press Weight: 0.571kg ISBN: 9780367541163ISBN 10: 0367541165 Pages: 322 Publication Date: 15 September 2022 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsProgrammed Death 1 Receptor (PD-1)-mediated Immunomodulatory Effects in Pancreatic Cancer. Nuclear Factor Kappa-B: Bridging Inflammation and Cancer. The S100A7/8/9 Proteins: Novel Biomarker and Therapeutic Targets for Solid Tumor Stroma. Nuclear Receptor Coactivators: Mechanism and Therapeutic Targeting In Cancer. Liquid Biopsies for Pancreatic Cancer: A Step Towards Early Detection. Targeting Subgroup-specific Cancer Epitopes for Effective Treatment of Pediatric Medulloblastoma. Aberrant Methylation of UC Promoters in Human Pancreatic Ductal Carcinomas. Receptor Tyrosine Kinase Signaling Pathways as a Goldmine for Targeted Therapy in Head and Neck Cancers. Molecular Drivers in Lung Adenocarcinoma: Therapeutic Implications. Molecular Mediator of Prostate Cancer Progression and Its Implication in Therapy. Therapeutic Options for Prostate Cancer: A Contemporary Update. Regulation and Targeting of MUCINS in Pancreatic Cancer. Targeted Therapy for Cancer Stem Cells.ReviewsThe book discusses the specific genes that regulate several malignancies and the available and optimized targeted therapies to treat such cancers. This is an excellent book that provides an interesting account on transcriptional dysregulation in cancer and how transcriptional regulation by therapeutic agents serves as a platform to design clinical trials in the questof cures for cancer. It is quite unique in discussing this complex subject matter concisely and clearly. - Omer Iqbal, Loyola University Medical Center Author InformationSurinder K. Batra is a Professor and Chairman of the Department of Biochemistry and Molecular Biology at the University of Nebraska Medical Center. Dr. Batra studies the functions of mucins in the progression of different malignancies. His recent studies demonstrated the molecular mechanism for the progression and metastasis of multiple cancers. His investigations led to developing several targeted therapies for different tumors. Based on his mechanistic and translational studies, different targets entered into Phase I/II trials for various cancers. Moorthy P. Ponnusamy is an Associate Professor of Biochemistry and Molecular Biology at the University of Nebraska Medical Centre. Dr. Ponnusamy’s research background reflects a keen interest in understanding the molecular mechanisms of cancer stem cell-mediated progression and metastatis of pancreatic cancer. His recent studies discovered the specific mechanism for pancreatic cancer stem cell maintenance and its impact on metastatis. He is developing small molecules to target cancer stem cell populations. Tab Content 6Author Website:Countries AvailableAll regions |
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