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OverviewGene Regulation provides a complete and concise picture of the processes regulating gene expression in higher organisms and man. The second edition of this textbook has been updated to reflect the scientific progress made in this area over the last four years. In particular, new sections have been added on X-chromosome inactivation, genomic imprinting, locus control regions, negative regulation of transcription and transcriptional regulation by oncogenes. As in the first edition, the opening chapters cover the mechanisms by which gene expression could be regulated at different levels and establish that control is primarily at the level of gene transcription. Having discussed examples of post-transcriptional regulation, the remaining chapters focus on the mechanisms by which transcription is regulated both at the level of chromatin structure and by specific regulatory transcription factors. A final chapter deals with the malregulation of gene expression which occurs in human diseases, notably cancer, and should be of particular interest to clinicians and medical students. An understanding of gene regulation is essential for a full comprehension of processes as diverse as normal development and human disease. This work should therefore be of interest to postgraduate and undergraduate students in all areas of cell and molecular biology, biochemistry and genetics. Researchers in other areas of biology, medical students and clinicians should also find this concise account of a key process in modern biology to be useful background reading. This book should be of interest to intermediate and advanced undergraduate students of biochemistry, genetics and molecular biology; and clinicians interested in these fields. Full Product DetailsAuthor: David S. LatchmanPublisher: Oxford University Press Imprint: Nelson Thornes Ltd Edition: 2nd ed. 1994 Dimensions: Width: 17.80cm , Height: 1.50cm , Length: 25.40cm Weight: 1.110kg ISBN: 9780412602009ISBN 10: 0412602008 Pages: 288 Publication Date: 24 November 1994 Audience: College/higher education , Undergraduate , Postgraduate, Research & Scholarly Replaced By: 9780412817908 Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsReviewsReviews from the first edition:; It is well written, lucid and makes easy reading. The illustrations are well thought out, plentiful, and easy to follow. There is an excellent reference list at the end of each chapter - Society for General Microbiology Quarterly; The text is lucid and free of jargon and generally a pleasure to read - The Lancet; Latchman has done a grand job of synthesis, and these chapters could form a useful background to more seasoned workers than undergraduates...Readers will be rewarded by an up-to-date, but very succinct, account of progress in an exciting and important area of modern biology - Times Higher Education Supplement; This is a timely and attractive short textbook that will be of considerable value to senior undergraduates, postgraduates, those entering the field for the first time, and their teachers. I shall be enthusiastically recommending it to my students; perhaps then they will understand my lectures and be able to answer the examination questions! - Applied Biodiversity and Biotechnology; This is an excellent student book. - Cellular and Molecular Biology; Rather than compiling a dry series of facts, an excellent pedagogue has threaded through the various chapters a logical scheme that allows smooth transitions from one regulatory mechanism to another and makes the reading actually quite enjoyable. Practical examples are judiciously chosen and introduced with extreme clarity...this book does a wonderful job of mentioning everyone's favourite hypotheses while placing them in a larger context and keeping alternative possibilities and interpretations wide open. Latchman's review should be highly recommended to motivated undergraduate and graduate students who want to immerse themselves in the facinating world of gene regulation - Trends in Genetics; The fast pace of research in this field makes the task of distilling it to under 300 pages a daunting one, but Latchman has succeeded admirably. The straighforward style of the text is complemented by clear, uncluttered diagrams, and the book will be welcomed by teachers as well as students in molecular biology and genetics - SGM Quarterly; I am glad to say that David Latchman, while updating his text for the second edition, has maintained all the appealing features of the first edition without any significant increase in length. The writing is clear, concise and authoritative. The simple line drawings are excellent. The contents focus on the principles of regualtion and are illustrated by well-chosen examples that do not overwhelm the reader with detail... We certainly do live in exciting times and students and teachers will find that David Latchman captures them in this excellent book. - Biotechnology and Applied Biochemistry; This book serves as an important resource for any reader interested in the molecular basis of gene regulation. - Genetic Counselling; Reviews from the first edition:; The examples used to explain the variation in eukaryotic gene regulation are explained clearly and the diagrams [are] easy to understand ... This book may serve as a useful introduction to the field - Trends in Cell Biology; ...a great teaching aid - The Genetic Engineer and Biotechnologist. Reviews from the first edition: It is well written, lucid and makes easy reading. The illustrations are well thought out, plentiful, and easy to follow. There is an excellent reference list at the end of each chapter - Society for General Microbiology Quarterly; The text is lucid and free of jargon and generally a pleasure to read - The Lancet; Latchman has done a grand job of synthesis, and these chapters could form a useful background to more seasoned workers than undergraduates...Readers will be rewarded by an up-to-date, but very succinct, account of progress in an exciting and important area of modern biology - Times Higher Education Supplement; This is a timely and attractive short textbook that will be of considerable value to senior undergraduates, postgraduates, those entering the field for the first time, and their teachers. I shall be enthusiastically recommending it to my students; perhaps then they will understand my lectures and be able to answer the examination questions! - Applied Biodiversity and Biotechnology; This is an excellent student book. - Cellular and Molecular Biology; Rather than compiling a dry series of facts, an excellent pedagogue has threaded through the various chapters a logical scheme that allows smooth transitions from one regulatory mechanism to another and makes the reading actually quite enjoyable. Practical examples are judiciously chosen and introduced with extreme clarity...this book does a wonderful job of mentioning everyone's favourite hypotheses while placing them in a larger context and keeping alternative possibilities and interpretations wide open. Latchman's review should be highly recommended to motivated undergraduate and graduatestudents who want to immerse themselves in the facinating world of gene regulation - Trends in Genetics; The fast pace of research in this field makes the task of distilling it to under 300 pages a daunting one, but Latchman has succeeded admirably. The straighforward style of the text is complemented by clear, uncluttered diagrams, and the book will be welcomed by teachers as well as students in molecular biology and genetics - SGM Quarterly; I am glad to say that David Latchman, while updating his text for the second edition, has maintained all the appealing features of the first edition without any significant increase in length. The writing is clear, concise and authoritative. The simple line drawings are excellent. The contents focus on the principles of regualtion and are illustrated by well-chosen examples that do not overwhelm the reader with detail.... We certainly do live in exciting times and students and teachers will find that David Latchman captures them in this excellent book. - Biotechnology and Applied Biochemistry; This book serves as an important resource for any reader interested in the molecular basis of gene regulation. - Genetic Counselling; Reviews from the first edition: The examples used to explain the variation in eukaryotic gene regulation are explained clearly and the diagrams [are] easy to understand ... This book may serve as a useful introduction to the field - Trends in Cell Biology; ...a great teaching aid - The Genetic Engineer and Biotechnologist. Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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