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Overview"""Gene Regulation"" provides a view of gene control systems from a eukaryotic standpoint, and tries to redress the bias towards prokaryotic control models. The text explores a variety of regulational strategies and defines their functional significance to the organism as a whole. The opening chapters examine the possible processes and mechanisms by which genes could be controlled at different levels, and establish that the key control structures lie at the level of gene transcription. Further chapters continue with an examination of the various steps in transcriptional regulation and explain how events at the molecular level finally have their impact on the biology of the organism via the expression of a diversity of proteins. The final section takes a look at the role of malregulation of gene expression in causing human diseases, particularly in relation to certain forms of cancer. This book should appeal to a wide range of intermediate and advanced students of molecular biology, biochemistry, genetics and clinicians working in these areas." Full Product DetailsAuthor: David S. LatchmanPublisher: Kluwer Academic Publishers Group Imprint: Kluwer Academic Publishers Edition: 1990 ed. Weight: 0.489kg ISBN: 9780044452430ISBN 10: 0044452438 Pages: 220 Publication Date: 24 May 1990 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Paperback Publisher's Status: Out of Print Availability: Out of stock  Table of ContentsPart 1 Tissue-specific expression of proteins and messenger RNAs: tissue-specific expression of proteins and of messenger RNAs. Part 2 the DNA of different cell types is similar in both amount and type: DNA loss; DNA amplification; DNA rearrangement. Part 3 Regulation at transcription: levels of gene regulation; evidence for transcriptional regulation; regulation at transcriptional elongation. Part 4 Post-transcriptional regulation: regulation after transcription?; regulation of RNA splicing; regulation of RNA transport and of RNA stability; regulation of translation. Part 5 Transcriptional control - chromatin structure: commitment to the differentiated state and its stability; chromatin structure; changes in chromatin structure in active or potentially active genes; other changes in DNA and its associated proteins in active or potentially active genes; DNaseI hypersensitive sites in active or potentially active genes. Part 6 Transcriptional control - DNA sequence elements; short sequence elements located within or adjacent to the gene promoter; enhancers; role of repeated sequences; regulation of transcription by RNA polymerases I and III. Part 7 Transcriptional control - transcription factors: DNA binding by transcription factors; activation of transcription; what activates the activators? Part 8 Gene regulation and cancer: proto-oncogenes; elevated expression of oncogenes; transcription factors as oncogenes. Part 9 Conclusions and future prospects.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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