Overview

Completion of the sequence of the human genome represents an unpar- leled achievement in the history of biology. The project has produced nearly complete, highly accurate, and comprehensive sequences of genomes of s- eral organisms including human, mouse, drosophila, and yeast. Furthermore, the development of high-throughput technologies has led to an explosion of projects to sequence the genomes of additional organisms including rat, chimp, dog, bee, chicken, and the list is expanding. The nearly completed draft of genomic sequences from numerous species has opened a new era of research in biology and in biomedical sciences. In keeping with the interdisciplinary nature of the new scientific era, the chapters in Gene Mapping, Discovery, and Expression: Methods and Protocols recapitulate the necessity of integration of experimental and computational tools for solving - portant research problems. The general underlying theme of this volume is DNA sequence-based technologies. At one level, the book highlights the importance of databases, genome-browsers, and web-based tools for data access and ana- sis. More specifically, sequencing projects routinely deposit their data in p- licly available databases including GenBank, at the National Center of Biotechnology (NCBI) in the United States; EMBL, maintained by the European Bioinformatics Institute; and DDBJ, the DNA Data Bank of Japan. Currently, several browsers offer facile access to numerous genomic DNA sequences for gene mapping and data retrieval.

Full Product Details

Author:   Minou Bina
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2006 ed.
Volume:   338
Dimensions:   Width: 15.50cm , Height: 2.40cm , Length: 23.50cm
Weight:   0.758kg
ISBN:  

9781588295750

ISBN 10:   1588295753
Pages:   334
Publication Date:   01 April 2006
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Use of Genome Browsers to Locate Your Favorite Genes Minou Bina Methods for Identifying and Mapping Recent Segmental and Gene Duplications in Eukaryotic Genomes Razi Khaja, Jeffrey R. MacDonald, Junjun Zhang, and Stephen W. Scherer Identification and Mapping of Paralogous Genes on a Known Genomic DNA Sequence Minou Bina Quantitative DNA Fiber Mapping in Genome Research and Construction of Physical Maps Heinz-Ulrich G. Weier and Lisa W. Chu PRINS for Mapping Single-Copy Genes Avirachan T. Tharapel and Stephen S. Wachtel VISTA Family of Computational Tools for Comparative Analysis of DNA Sequences and Whole Genomes Inna Dubchak and Dmitriy V. Ryaboy Computational Prediction of cis-Regulatory Modules from Multispecies Alignments Using Galaxy, Table Browser, and GALA Laura Elnitski, David King, and Ross C. Hardison Comparative Promoter Analysis in Vertebrate Genomes with the CORG Workbench Christoph Dieterich and Martin Vingron cis-Regulatory Region Analysis Using BEARR Vinsensius Berlian Vega A Database of 9-Mers from Promoter Regions of Human Protein-Coding Genes Minou Bina, Phillip Wyss, and Syed Rehan Shah A Program Toolkit for the Analysis of Regulatory Regions of Genes Phillip Wyss, Sheryl A. Lazarus, and Minou Bina Analysis of Allele-Specific Gene Expression Julian C. Knight Construction of microRNA-Containing Vectors for Expression in Mammalian Cells Yoko Fukuda, Hiroaki Kawasaki, and Kazunari Taira Mining Microarray Data at NCBI's Gene Expression Omnibus (GEO) Tanya Barrett and Ron Edgar The Stanford Microarray Database: A User's Guide Jeremy Gollub, Catherine A. Ball, and Gavin Sherlock Detecting Nucleosome Ladders on Unique DNA Sequences in Mouse Liver Nuclei Tomara J. Fleury, Alfred Cioffi, and Arnold Stein DNA Methyltransferase Probing of DNA-Protein Interactions Scott A. Hoose and Michael P. Kladde Protein Binding Microarrays (PBMs) for Rapid, High-Throughput Characterization of the Sequence Specificities of DNA Binding Proteins Michael F. Berger and Martha L. Bulyk Quantitative Profiling of Protein-DNA Binding on Microarrays Jiannis Ragoussis, Simon Field, and Irina A. Udalova Analysis of Protein-DNA Binding by Streptavidin-Agarose Pulldown Kenneth K. Wu Isolation and Mass Spectrometry of Specific DNA Binding Proteins Mariana Yaneva and Paul Tempst Isolation of Transcription Factor Complexes by In Vivo Biotinylation Tagging and Direct Binding to Streptavidin Beads Patrick Rodriguez, Harald Braun, Katarzyna E. Kolodziej, Ernie de Boer, Jennifer Campbell, Edgar Bonte, Frank Grosveld, Sjaak Philipsen, and John Strouboulis Index

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