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OverviewProteins lie at the heart of almost all biological processes and have an incredibly wide range of activities. Central to the function of all proteins is their ability to adopt, stably or sometimes transiently, structures that allow for interaction with other molecules. An understanding of the structure of a protein can therefore lead us to a much improved picture of its molecular function. This realisation has been a prime motivation of recent Structural Genomics projects, involving large-scale experimental determination of protein structures, often those of proteins about which little is known of function. These initiatives have, in turn, stimulated the massive development of novel methods for prediction of protein function from structure. Since model structures may also take advantage of new function prediction algorithms, the first part of the book deals with the various ways in which protein structures may be predicted or inferred, including specific treatment of membrane and intrinsically disordered proteins. A detailed consideration of current structure-based function prediction methodologies forms the second part of this book, which concludes with two chapters, focusing specifically on case studies, designed to illustrate the real-world application of these methods. With bang up-to-date texts from world experts, and abundant links to publicly available resources, this book will be invaluable to anyone who studies proteins and the endlessly fascinating relationship between their structure and function. Full Product DetailsAuthor: Daniel John RigdenPublisher: Springer Imprint: Springer Edition: Softcover reprint of hardcover 1st ed. 2009 Dimensions: Width: 15.50cm , Height: 1.80cm , Length: 23.50cm Weight: 0.562kg ISBN: 9789048180585ISBN 10: 9048180589 Pages: 328 Publication Date: 10 November 2010 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsGenerating and Inferring Structures.- Ab Initio Protein Structure Prediction.- Fold Recognition.- Comparative Protein Structure Modelling.- Membrane Protein Structure Prediction.- Bioinformatics Approaches to the Structure and Function of Intrinsically Disordered Proteins.- From Structures to Functions.- Function Diversity Within Folds and Superfamilies.- Predicting Protein Function from Surface Properties.- 3D Motifs.- Protein Dynamics: From Structure to Function.- Integrated Servers for Structure-Informed Function Prediction.- Case Studies: Function Predictions of Structural Genomics Results.- Prediction of Protein Function from Theoretical Models.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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