Overview

"Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the ""Handbook of Experimental Pharmacology"" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes."

Full Product Details

Author:   Juergen Eckel ,  Karine Clément
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2022
Volume:   274
Weight:   1.041kg
ISBN:  

9783030999940

ISBN 10:   3030999947
Pages:   513
Publication Date:   22 July 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Part I Obesity. Epidemiology of Obesity.- The Circadian Clock and Obesity.- Nutrition and Microbiome.- From Obesity to Diabetes: The Role of the Adipose Organ.- Targeting Epicardial Fat in Obesity and Diabetes Pharmacotherapy.- The Enteroendocrine System in Obesity.- Insights from Studies of White Adipose Tissue Using Single-Cell Approaches.- Obesity-Related Insulin Resistance: The Central Role of Adipose Tissue Dysfunction.- Obesity, Senescence, and Senolytics.- Obesity and Obstructive Sleep Apnea.- Part II Diabetes and Complications. Inter-Organ Crosstalk in the Development of Obesity-Associated Insulin Resistance.- Islet Inflammation and β Cell Dysfunction in Type 2 Diabetes.- NAFLD and NASH: The Metabolically Diseased Liver.- Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities.- Diabetic Peripheral Neuropathy.- Part III Lifestyle Modifications and Future Treatments. Weight Loss Strategies.- PhysicalActivity, Obesity and Weight Loss Maintenance.- Bariatric/Metabolic Surgery.- Drugs for Treating Obesity.- Novel Drugs for Diabetes Therapy.- Novel Approaches to Restore Pancreatic Beta-Cell Mass and Function.- Precision Medicine and Obesity.- Targeting the Enteroendocrine System for Treatment of Obesity.

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