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OverviewThis volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes. Full Product DetailsAuthor: Marc Daeron , Falk NimmerjahnPublisher: Springer International Publishing AG Imprint: Springer International Publishing AG Edition: Softcover reprint of the original 1st ed. 2014 Volume: 382 Dimensions: Width: 15.50cm , Height: 2.30cm , Length: 23.50cm Weight: 6.613kg ISBN: 9783319379098ISBN 10: 3319379097 Pages: 424 Publication Date: 23 August 2016 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsPart I : Old and new FcRs Hiromi Kubagawa, Yoshiki Kubagawa, Dewitt Jones, Tahseen H. Nasti, Mark Walter, and Kazuhito Honjo The Old but New IgM Fc Receptor (FcμR) F.J. Li, W.J. Won, E.J. Becker Jr., J.L. Easlick, E. Tabengwa, R. Li, M. Shakhmatov, P.D. Burrows, and R.S. Davis Emerging Roles for FCRL Family Members in Lymphocyte Biology and Disease Leo C. James Intracellular antibody immunity and the cytosolic Fc receptor TRIM21 Part II: FcR signaling Anna Niarakis, Yacine Bounab, Luca Grieco, Roman Roncagalli, Jérôme Garin, Bernard Malissen, Marc Daëron, Denis Thieffry Computational modeling of the main signaling pathways involved in mast cell activation Tarik Attout, Andres Floto and Pierre Launay Calcium channels in FcR signaling Marcel Kuhny, Carolin N. Zorn, and Michael Huber Regulation of FcεRI signaling by lipid phosphatases Part III: FcR biology Marc Daëron Fc Receptors as Adaptive Immunoreceptors Jerrard M Hayes, Eoin FJ Cosgrave, Weston B Struwe, Mark Wormald, Gavin P. Davey, Roy Jefferis, Pauline M Rudd Glycosylation and Fc Receptors Birgitta Heyman Antibodies as natural adjuvants Sanae Ben Mkaddem, Ivy Christou, Elisabetta Rossato, Laureline Berthelot, Agnès Lehuen and Renato C. Monteiro IgA, IgA receptors and their anti-inflammatory properties Stylianos Bournazos, David J. DiLillo and Jeffrey V. Ravetch Humanized mice to study FcγR function Dilip K. Challa, Ramraj Velmurugan, Raimund J. Ober and E. Sally Ward FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions. Part IV: FcRs and disease Xinrui Li, Andrew W Gibson and Robert P Kimberly Human FcR polymorphism and disease. Hanane el Bannoudi, Andreea Ioan-Facsinay and René E. M. Toes Bridging auto-antibodies and arthritis; the role of Fc Receptors P. Mark Hogarth, Jessica C. Anania, Bruce D. Wines The FcγR of humans and non-human primates and their interaction with IgG: Implications for induction of inflammation, resistance to infection and the use of therapeutic monoclonal antibodies Part V: FcRs and therapeutic antibodies Ann L White, Stephen A Beers and Mark S. Cragg FcgRIIB as a key determinant of agonistic antibody efficacy Jantine E. Bakema and Marjolein van Egmond Fc receptor dependent mechanisms of monoclonal antibody therapy of cancer; professionals at work Sybille Böhm, Daniela Kao and Falk Nimmerjahn Sweet and Sour: The role of glycosylation for the anti-inflammatory activity of immunoglobulin GReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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