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OverviewThis volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology. Full Product DetailsAuthor: Jeffrey V. Ravetch , Falk NimmerjahnPublisher: Springer Nature Switzerland AG Imprint: Springer Nature Switzerland AG Edition: 1st ed. 2019 Volume: 423 Weight: 0.454kg ISBN: 9783030310523ISBN 10: 3030310523 Pages: 150 Publication Date: 19 September 2019 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsIgG Fc receptors: evolutionary considerations.- Role of FcgRs in Antibody Based Cancer Therapy.- Anti-inflammatory Activity of IgG-Fc.- IgG Fc glycosylation in human immunity.- IgE Glycosylation in Health and Disease.- Immune Complex Vaccination.- Fc receptors in anti-microbial protection.Reviews"""The audience includes a wide range of individuals with backgrounds in basic immunology. This includes graduate students, postdoctoral fellows, and principal investigators, as well as clinical fellows and residents in the fields of rheumatology and clinical immunology."" (Richard Coico, Doody's Book Reviews, March 6, 2020)" The audience includes a wide range of individuals with backgrounds in basic immunology. This includes graduate students, postdoctoral fellows, and principal investigators, as well as clinical fellows and residents in the fields of rheumatology and clinical immunology. (Richard Coico, Doody's Book Reviews, March 6, 2020) Author InformationJeffrey V. Ravetch Theresa and Eugene M. Lang Professor Department Leonard Wagner Laboratory of Molecular Genetics and Immunology Rockefeller University 1230 York Avenue, Box 98 New York, NY 10021, USA ravetch@mail.rockefeller.edu Falk Nimmerjahn Professor for Immunology and Genetics Chairman of the Institute of Genetics Head of the Department of Biology Department of Biology University of Erlangen-Nuernberg Erwin-Rommelstr. 3 91058 Erlangen, Germany falk.nimmerjahn@fau.de Tab Content 6Author Website:Countries AvailableAll regions |
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