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OverviewEscherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targetsand development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development. Full Product DetailsAuthor: Gad Frankel , Eliora Z RonPublisher: Springer International Publishing AG Imprint: Springer International Publishing AG Edition: 1st ed. 2018 Volume: 416 Weight: 0.547kg ISBN: 9783319996639ISBN 10: 3319996630 Pages: 242 Publication Date: 13 November 2018 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsShigella and enteroinvasive Escherichia coli.- Enteroaggregative Escherichia coli.- The Type III Secretion System of pathogenic Escherichia coli.- Modulation of host cell processes by T3SS effectors.- The 2011 German enterohemorrhagic Escherichia coli O104:H4 outbreak – the danger is still out there.- Extraintestinal Pathogenic Escherichia coli.- Pandemic bacteremic Escherichia coli strains: evolution and emergence of drug resistant pathogens.- Current Trends in Antimicrobial Resistance of Escherichia coli.- Vaccines against Escherichia coli.ReviewsAuthor InformationProf. Dr. Gad FrankelDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom, g.frankel@imperial.ac.uk Prof. Dr. Eliora Z. RonDepartment of Molecular Microbiology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel, eliora@post.tau.ac.il Tab Content 6Author Website:Countries AvailableAll regions |
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