Overview

**Selected for Doody’s Core Titles® 2024 in Clinical Genetics** Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth. Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.

Full Product Details

Author:   Chandra S. Boosani (Assistant Professor, Department of Translational Research, College of Osteopathic Medicine, Pacific Western University School of Health Sciences, CA, USA) ,  Ritobrata Goswami (Assistant Professor, School of Bioscience, IIT Kharagpur, West Bengal, India)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   1.340kg
ISBN:  

9780128239315

ISBN 10:   012823931
Pages:   666
Publication Date:   05 December 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Introduction to epigenetic mechanisms 2. Epigenetic signatures that maintain stemness in pluripotent and mesenchymal stem cells 3. Cell-cell and Cell-matrix interactions mediated by histone deacetylases 4. Enhanced cell proliferation and altered gene expression due to actions of DNA methyltransferases 5. Histone deacetylases and regulation of gene expression during cell proliferation 6. Epigenetic mediators that promote cytoskeletal reorganization and cell migration 7. Inhibition of cellular apoptosis and senescence by unique epigenetic proteins 8. Epigenetic mechanisms involved in the regulation of necrosis and pyknosis 9. Epigenetic control over cell division in pathological conditions 10. Regulated expression of tumor suppressor proteins by DNA methyltransferases during cell cycle progression 11. Role of histone deacetylases in regulating cell cycle progression 12. Phenotype switch and cell differentiation in immune and non-immune cells regulated by different epigenetic mediators 13. Epigenetic pathways that promote cellular autophagy 14. Epigenetic inducers of Cell growth and survival 15. Microbial compounds as potential inducers of epigenetic mechanisms during infections 16. Current epigenetic drugs and their target proteins with potential use in disease treatment 17. Prospects of epigenetic drugs in combination therapy

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Author Information

Dr. Chandra S. Boosani is an Assistant Professor at the Genetics, Epigenetics & Molecular Biology Lab, within the Department of Translational Research, at the College of Osteopathic Medicine, Pacific Western University School of Health Sciences, CA, U.S.A. His research focuses on developing and testing anticancer proteins, and identifying mechanisms of epigenetic drug action, with emphasis on developing recombinant proteins, drug testing in live mice, and analyzing sequencing data. Dr. Boosani has published in such peer reviewed journals as Seminars in Cancer Biology, Blood, Pharmaceuticals, Gene Regulation and Systems Biology, and Protein Expression and Purification. Ritobrata Goswami is a Assistant Professor in the School of Bioscience, IIT Kharagpur, West Bengal, India.

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