Overview

Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

Full Product Details

Author:   Tapas Kumar Kundu
Publisher:   Springer
Imprint:   Springer
Edition:   2012
Volume:   61
Dimensions:   Width: 15.50cm , Height: 3.20cm , Length: 23.50cm
Weight:   1.318kg
ISBN:  

9789400745247

ISBN 10:   9400745249
Pages:   689
Publication Date:   13 November 2012
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

PART I: EPIGENETICS AND EVOLUTION.- 1.1 Chromatin Organization, Epigenetics and Differentiation: An evolutionary perspective.- 1.2 Secondary structures of the core histone N-terminal tails: their role in regulating chromatin structure.- 1.3 Megabase replication domains along the human genome: Relation to chromatin structure and genome organization.- 1.4 Role of DNA methyltransferases in epigenetic regulation in bacteria.- PART II: DEVELOPMENTAL EPIGENETICS.- 2.1 Metabolic aspects of epigenome: Coupling of S-adenosylmethionine synthesis and gene regulation on chromatin by SAMIT module.- 2.2 Epigenetic regulation of male germ cell differentiation.- 2.3 Epigenetic Regulation of Skeletal Muscle Development and Differentiation.- 2.4 Small changes, big effects: chromatin goes aging.- 2.5 Homeotic gene regulation: A paradigm for epigenetic mechanisms underlying organismal development.- PART III: EPIGENETICS AND TRANSCRIPTION REGULATION.- 3.1 Basic mechanisms in RNA Polymerase I transcription of the ribosomal RNA genes.- 3.2 The RNA polymerase II transcriptional machinery and its epigenetic context.- 3.3 RNA polymerase III transcriptions - regulated by chromatin structure and regulator of nuclear chromatin organization.- 3.4. The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in humans.- 3.5 Histone variants and Transcription regulation.- 3.6 Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View.- 3.7 Chromatin structure and organization: the relation with gene expression during development and disease.- PART IV: EPIGENETICS AND DISEASE.- 4.1 Epigenetics and cancer: Development, Differentiation and Pathobiology.- 4.2 Epigenetic Regulation of Cancer Stem Cell Gene Expression.- 4.3 Role of Epigenetic Mechanisms in the Vascular Complications of Diabetes.- 4.4 Epigenetic changes in inflammatory and autoimmune diseases.- 4.5 Epigenetic regulation of HIV-1 persistence and evolving strategies for virus eradication.- 4.6 Epigenetics in Parkinson's and Alzheimer's diseases.- 4.7 Cellular Redox, Epigenetics and Diseases.- PART V: UNDERSTANDING OF EPIGENETICS: A CHEMICAL BIOLOGY APPROACH AND EPIGENETIC THERAPY.- 5.1 Stem cell plasticity in development and cancer: Epigenetic origin of cancer stem cells.- 5.2 Histone acetylation as a therapeutic target- Implication of nanodelivery.- 5.3 DNA methylation and Cancer.- 5.4 Role of epigenetics in inflammation-associated diseases.- 5.5 Plasmodium falciparum: Epigenetic control of var gene regulation and disease.

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