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Awards
OverviewEpigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. Full Product DetailsAuthor: J. David Sweatt (McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA) , Michael J. Meaney (Douglas Institute, McGill University, Montreal, Canada) , Eric J. Nestler (Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA) , Schahram Akbarian (Department of Psychiatry, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA)Publisher: Elsevier Science Publishing Co Inc Imprint: Academic Press Inc Dimensions: Width: 19.10cm , Height: 2.30cm , Length: 23.50cm Weight: 0.990kg ISBN: 9780123914941ISBN 10: 0123914949 Pages: 374 Publication Date: 27 February 2013 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents"1. An Overview of the Molecular Basis of Epigenetics J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian 2. Histone modifications in the nervous system and neuropsychiatric disorders Morgan Bridi and Edwin ""Ted"" Abel 3. Active DNA Demethylation and 5-Hydroxymethylcytosine Junjie U. Guo, Guo-li Ming and Hongjun Song 4. Maternal Behavior Tie Yuan Zhang, Christian Caldji, Josie C. Diorio, Sabine Dhir, Gustavo Turecki, and Michael J. Meaney 5. Epigenetic Mechanisms in Learning and Memory Jeremy J. Day and J. David Sweatt 6. Drug Addiction and Reward Alfred J. Robison, Jian Feng, and Eric J. Nestler 7. The Mind and its Nucleosomes – Chromatin (dys)regulation in Major Psychiatric Disease Rahul Bharadwaj, Cyril J. Peter, and Schahram Akbarian 8. HDAC inhibitors as novel therapeutics in Aging, and Alzheimer's disease Alexi Nott, Daniel M. Fass, Stephen J. Haggarty, and Li-Huei Tsai 9. Cell Differentiation in the CNS, Neuronal Fate Determination, and Development Yi Eve Sun 10. Imprinting in the CNS and Neurodevelopmental Disorders Weston T. Powell and Janine LaSalle 11. Neuronal Genomic and Epigenetic Diversity Michael J. McConnell and Fred H. Gage 12. Adult Neurogenesis Jenny Hsieh, Hongjun Song 13. Transgenerational Inheritance in Mammals Isabelle M. Mansuy, Rahia Mashoodh and Francis A. Champagne 14. Open Questions and Future Approaches in Neuroepigenetics J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian"ReviewsSweatt, Meaney, Nestler, and Akbarian present the first foundational work to address molecular, cellular, behavioral, and clinical roles for epigenetic mechanisms in the nervous system.This unique book is targeted for physicians and scientists, as well as researchers and students. --Reference & Research Book News, October 2013 Author InformationDr. Nestler is the Nash Family Professor of Neuroscience at the Mount Sinai School of Medicine in New York, where he serves as Chair of the Department of Neuroscience and Director of the Friedman Brain Institute. He received his B.A., Ph.D., and M.D. degrees, and psychiatry residency training, from Yale University. He served on the Yale faculty from 1987-2000, where he was the Elizabeth Mears and House Jameson Professor of Psychiatry and Neurobiology, and Director of the Division of Molecular Psychiatry. He moved to Dallas in 2000 where he served as the Lou and Ellen McGinley Distinguished Professor and Chair of the Department of Psychiatry at The University of Texas Southwestern Medical Center until moving to New York in 2008. Dr. Nestler is a member of the Institute of Medicine and a Fellow of the American Academy of Arts and Sciences. The goal of Dr. Nestler's research is to better understand the molecular mechanisms of addiction and depression based on work in animal models, and to use this information to develop improved treatments of these disorders. Schahram Akbarian studied medicine at the Freie Universitaet Berlin, Germany. He is a board certified psychiatrist and molecular neuroscientist who trained at the Massachusetts General Hospital in Boston, the Whitehead Institute for Biomedical Research in Cambridge and the University of California at Irvine. In 2002, he joined the University of Massachusetts Medical School in Worcester where he established a research program in psychiatric epigenetics and served as the Director of the Brudnick Neuropsychiatric Research Institute. Presently, he heads the Division of Psychiatric Epigenomics in the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine. He is a former recipient of the Klerman award from the Brain & Behavior Research Foundation, the Judith Silver Memorial award of the National Alliance for the Mentally Ill, the Outstanding resident award of the National Institute of Mental Health, and the Eva King Killam Award for Outstanding Translational Research, American College of Neuropsychopharmacology. Dr. Akbarian has been a principal investigator on National Institutes of Health-funded research projects since 2001and published close to 100 articles in scientific journals and book chapters. He is a member of professional societies such as the American College of Neuropsychopharmacology and presently serves on the Scientific Advisory Board of the Brain & Behavior Research Foundation and on Editorial Boards of various journals in the field Tab Content 6Author Website:Countries AvailableAll regions |
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