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OverviewEpigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company, and a substantial number of biotechnology companies, targeting epigenetic processes to treat diseases ranging from cancer to Huntington’s disease and from inflammation to sickle cell anaemia. This book aims to provide an overview of the key topics adopted in current epigenetic drug discovery programmes with a focus on major developments and new technologies. Importantly, the book incorporates case studies and outlines the key challenges and techniques employed to overcome them. The book is an ideal resource for researchers in both industry and academia with an interest in epigenetic and genetic factors involved in drug discovery, target ID and validation. The book is also an excellent introduction for postgraduates interested in the interface between epigenetics and pharmaceuticals. Full Product DetailsAuthor: Ho Man Chan (AstraZeneca, USA) , Cheryl H Arrowsmith (University of Toronto, Canada)Publisher: Royal Society of Chemistry Imprint: Royal Society of Chemistry Volume: Volume 83 Dimensions: Width: 15.60cm , Height: 3.90cm , Length: 23.40cm Weight: 1.194kg ISBN: 9781837671106ISBN 10: 1837671109 Pages: 696 Publication Date: 30 September 2024 Audience: College/higher education , Professional and scholarly , Tertiary & Higher Education , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsIntroduction to Drug Discovery in Epigenetics Assay Development and Screening Strategies for Epigenetic Targets Mass Spectrometry and Chemical Biology Approaches for Deconvoluting Epigenetic Targets Recent Developments in the Structural Mechanism of Protein Methyltransferase Inhibition Epigenomic Sequencing Technologies Safety Consideration of Targeting Epigenetic Mechanisms Toward Understanding Pharmacological Modulation of DNA Methylation and Its Effects on Gene Expression Histone Deacetylases Chemical Targeting of Histone Acetyltransferases Histone Lysine Methyltransferases Inhibiting Arginine Methylation Histone Demethylases Targeting the Human Acetylation Reader Family: Bromodomain Proteins Targeting Histone Readers: Non-bromodomain Readers Arising Opportunities and Challenges of Targeting Chromatin Remodelers RNA Modifying Proteins: Emerging Targets for Drug Discovery Directly Targeting RNA with Drug-like Small Molecules Discovery and Development of Tazemetostat Menin Inhibitors: Discovery, Development and Clinical Translation Discovery of MTA-cooperative PRMT5 InhibitorsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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