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OverviewFull Product DetailsAuthor: Nediljko Budisa (Max-Planck-Institute of Biochemistry, Martinsried, Germany)Publisher: Wiley-VCH Verlag GmbH Imprint: Blackwell Verlag GmbH Dimensions: Width: 17.30cm , Height: 2.00cm , Length: 24.60cm Weight: 0.708kg ISBN: 9783527312436ISBN 10: 3527312439 Pages: 312 Publication Date: 15 November 2005 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: To order  Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us. Table of ContentsINTRODUCTION Classical Approaches for Protein Modification Protein Total Synthesis Basic Definitions and Taxonomy HISTORY OF AN EXPANDED AMINO ACID REPERTOIRE Cell-free Synthesis of Proteins Noncanonical Amino Acids as Tools for Studying Metabolism Genetic Code Engineering BASIC FEATURES OF THE CELLULAR TRANSLATION APPARATUS Ribosome-mediated Protein Synthesis tRNAs and tRNA Synthetases Translational Proofreading Ribosomal Decoding, Codon Bias and Translational Fidelity Context-dependent Recoding Post-translational Modifications GENETIC CODE ORGANISATION AND PROTEIN STRUCTURE The Universal Genetic Code Natural Variations in Codon Assignment Codon Reassignment and Codon Ambiguity REPROGRAMMING THE CELLULAR TRANSLATION MACHINERY Enzyme Specificity and Code Interpretation Reassigning Coding and Non-Coding Units In vitro Chemical and Enzymatic tRNA Aminoacylation Novel Codon-Anticodon Base Pairs Stop Codon Takover Suppression-Based Methods Future Approaches IMPLICATIONS AND INSIGHTS Evolution of the Amino Acid Repertoire Artificial Genetic Systems De novo Design of Organisms Chances and Risks APPLICATIONS FOR REPROGRAMMED CELLULAR TRANSLATION Genetically Encoded Protein Surface Diversity Applications in Structural Biology Atomic Mutations Protein Folding, Stability and Design Tailoring Protein Spectroscopy Protein-based Sensors Applications in Biomedicine Noncanonical Amino Acids with Neurological ActivityReviewsIn his book, Nediljko Budisa covers this highly interdisciplinary field and allows people not directly involved in protein engineering to get acquainted and up-to-date with the most recent and exciting developments. The book, which is the first of its kind dedicated entirely to this area of research, provides a comprehensive overview of the field. The book comprises seven chapters and has a clear structure supported by a multitude of fine illustrations, thus making the book a good read for those interested in protein engineering. ... Moreover, an excellent update on protein translation in general is given, which is useful for students and newcomers in the field. (...) The book provides an excellent introduction for first-time readers to the field of genetic-code engineering and, as stated on the back of the book, this is 'essential reading to all molecular life scientists who want to stay ahead in their research'. ChemBioChem The numerous examples illustrate the new prospects that are opened up by genetic code engineering. We can expect novel proteins with properties that cannot be foreseen in detail, when one considers that, even for polypeptides based on the 20 proteinogenic amino acids, the rules of folding are still not known. Angewandte Chemie International Edition ...besticht das Buch durch seine terminologische Klarheit und transdisziplinare Kompetenz. Es durfte ein Gewinn sein sowohl fur Interessierte an aktuellen Methoden der Molekularbiologie als auch fur jene, die von der Wandelbarkeit des universellen genetischen Codes einfach fasziniert sind. Nachrichten aus der Chemie Die umfangreiche Zahl der Beispiele belegt die neue Dimension, die das Code-Engineering erschliesst. Wir koennen neuartige Proteine mit nicht vorhersehbaren Eigenschaften erwarten, zumal schon fur Polypeptide mit den 20 proteinogenen Aminosauren der Faltungscode ungeloest ist. Aber auch Fragen zu neuen Einsatzfeldern in Technik und Pharmakologie, zur Evolution des genetischen Codes und zur Ethik der tiefgreifenden Veranderungen, die das Code-Engineering ermoeglicht, werden behandelt. Angewandte Chemie Wer sich uber diese brisante Materie informieren moechte, ist mit dem konkurrenzlosen Standardwerk von Budisa exzellent beraten. Das Science Fiction Jahr - Wissenschaftsbucher 2005 In his book, Nediljko Budisa covers this highly interdisciplinary field and allows people not directly involved in protein engineering to get acquainted and up-to-date with the most recent and exciting developments. The book, which is the first of its kind dedicated entirely to this area of research, provides a comprehensive overview of the field. The book comprises seven chapters and has a clear structure supported by a multitude of fine illustrations, thus making the book a good read for those interested in protein engineering. ... Moreover, an excellent update on protein translation in general is given, which is useful for students and newcomers in the field. (...) The book provides an excellent introduction for first-time readers to the field of genetic-code engineering and, as stated on the back of the book, this is 'essential reading to all molecular life scientists who want to stay ahead in their research'. ChemBioChem The numerous examples illustrate the new prospects that are opened up by genetic code engineering. We can expect novel proteins with properties that cannot be foreseen in detail, when one considers that, even for polypeptides based on the 20 proteinogenic amino acids, the rules of folding are still not known. Angewandte Chemie International Edition Author InformationNediljko Budisa is a group leader at the Max-Planck-Institute of Biochemistry in Martinsried near Munich (Germany). He studied Chemistry and Biology at the University of Zagreb (Croatia) before joining the group of Nobel Prize Winner Robert Huber at Martinsried to obtain his PhD degree. During postdoctoral work with R. Huber and L. Moroder he led an independent research team in protein engineering. In 2004, Dr. Budisa received the BioFuture Award of the German Federal Ministry for Research and Education. Tab Content 6Author Website:Countries AvailableAll regions |
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