Overview

With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology’s increased importance in environmental safety issues due to legislative directives established over the past ten years. Covering all principal areas of EPA concern, Endocrine Toxicology, Third Edition provides: putative endocrine disruptors and mechanisms of endocrine toxicity the history and status of the regulatory process mechanisms of toxic effects in various hormonal systems comparisons of the endocrine responses in humans, livestock, and wildlife testing methods in mammalian, fish, avian, and amphibian models valuable insight into the approaches of various personnel in the field, including: government officials who make and oversee policy; scientists in charge of development and validation of testing methods; basic researchers who identify toxic mechanisms; and manufacturers responsible for environmentally benign product certification

Full Product Details

Author:   J. Charles Eldridge (Wake Forest University, Winston-Salem, North Carolina, USA) ,  James T. Stevens (Wake Forest University, Winston-Salem, North Carolina, USA) ,  James T. Stevens (Wake Forest University, Winston-Salem, North Carolina, USA) ,  A. Wallace Hayes (Harvard School of Public Health, Andover, Massachusetts, USA)
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Edition:   3rd edition
Volume:   27
Dimensions:   Width: 15.20cm , Height: 2.50cm , Length: 22.90cm
Weight:   0.703kg
ISBN:  

9781420093094

ISBN 10:   1420093096
Pages:   424
Publication Date:   15 February 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Regulation of Endocrine Disruptive Chemicals in the United States. Pursuit of Endocrine Disruptors in Europe - the OECD Component. Impact of Endocrine Disruptor Policies and Regulations. The Hypothalamic-Pituitary-Gonadal Axis in Teleost Fish. The Hypothalamic-Pituitary-Gonadal Axis in Anuran Amphibians. The Hypothalamic-Pituitary-Gonadal Axis in Birds. The Hypothalamic-Pituitary-Gonadal Axis in Mammals. Comparing and Contrasting the Hypothalamic-Pituitary-Gonadal Axis in Different Vertebrate Classes. Male Reproductive Endpoints and the Rodent Hershberger Assay. Review of Bisphenol A by the National Toxicology Program. Pubertal Screening Assays in Rodents. Endocrine Disruption at Neuroendocrine and Neurotransmitter Sites. Endocrine Disruptor Interaction with Estrogen Receptors. Analysis of Endocrine Disruptors with Estrogen Reporter Systems. Time Dependent Embryotoxicity of the Endogenous Luteolysin, Prostaglandin F2alpha, in Ruminants. Actions of Endocrine Disruptors on the Thyroid Axis. Endocrine Disruption of Hormone Storage and Transport. Metal Toxicity in Mammalian Reproduction. Structure-Activity Modeling of Endocrine Disruptors. Overview of Endocrine Disruptor Ecotoxicity in Wildlife. Overview of USEPA Tests with Aquatic Vertebrates for Detecting and Assessing Endocrine Disrupting Chemicals. Biological Activity of Endocrine Disruptors in Aquatic Systems. Impact of Endocrine Disruptors on the Water Industry.

Reviews

This is an excellent review of the effects of toxic substances on endocrine axes in both humans and wildlife.... The ambitious goals of covering the expanse of molecular toxicology and regulatory action are met by the book's diverse chapters...... Because of the array of authors, the book serves as an excellent introduction to many areas related to endocrine toxicology....... The book does an excellent job of covering the topics in endocrine disruption that have become increasingly relevant over the last three decades. The classic mechanisms of endocrine disruption, namely alterations in estrogen and androgen signaling, are covered in two excellent chapters....As a whole, this book offers an excellent review of the effects of toxins on endocrine physiology with a particular strength in its coverage of government programs for monitoring these effects and the subsequent implications for regulatory policy. Because of the burgeoning knowledge in this area, this update is certainly appreciated, and subsequent editions will be welcome as our knowledge of endocrine disruption expands to other areas of endocrine physiology. Weighted Numerical Score: 94 - 4 Stars! [DOODY'S NOTES] [REVIEWER'S EXPERT OPINION] Robert Michael Sargis, M.D., Ph.D.(University of Chicago Medical Center)

Author Information

Eldridge, J. Charles; Stevens, James T.

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