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OverviewHaving received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that the experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort. Full Product DetailsAuthor: Robert J. Kavlock , George P. DastonPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Edition: Softcover reprint of the original 1st ed. 1997 Volume: 124 / 1 Dimensions: Width: 15.50cm , Height: 3.30cm , Length: 23.50cm Weight: 0.973kg ISBN: 9783642644085ISBN 10: 3642644082 Pages: 610 Publication Date: 28 January 2012 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents1 Introduction.- Section I: Recent Advances in Understanding Normal Development at the Biochemical and Molecular Level.- 2 Cardiac Morphogenesis: Formation and Septation of the Primary Heart Tube.- 3 Vertebrate Limb Development.- 4 Axial Skeleton.- 5 Molecular Mechanisms Regulating the Early Development of the Vertebrate Nervous System.- 6 Genetic Control of Kidney Morphogenesis.- 7 Palate.- Section II: Common Biochemical, Metabolic, and Physiological Mechanisms of Abnormal Development.- 8 Cell Death.- 9 Cellular Responses to Stress.- 10 Cell-Cell Interactions.- 11 Growth Factor Disturbance.- 12 Targeted Gene Disruptions as Models of Abnormal Development.- 13 Nucleotide Pool Imbalance.- 14 Interference with Embryonic Intermediary Metabolism.- 15 Alterations in Folate Metabolism as a Possible Mechanism of Embryotoxicity.- 16 Prostaglandin Metabolism.- 17 Reactive Intermediates.- 18 Hypoxia and Altered Redox Status in Embryotoxicity.- 19 Altered Embryonic pH.- 20 Maternal Physiological Disruption.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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