Overview

Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.

Full Product Details

Author:   J. Thomas August (John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.) ,  Ferid Murad (University of Texas Medical School, Houston, U.S.A.) ,  M. W. Anders (University of Rochester; Department of Pharmacology, New York, U.S.A.) ,  Joseph T. Coyle (McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   v. 43
Dimensions:   Width: 15.20cm , Height: 1.90cm , Length: 22.90cm
Weight:   0.620kg
ISBN:  

9780120329441

ISBN 10:   0120329441
Pages:   304
Publication Date:   06 November 1997
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

J. Collins, Foreword.A.P. Li, Preface.A.P. Li, Overview: Scientific Basis of Pharmacokinetic Drug-Drug Interactions.F.P. Guengerich, Role of Cytochrome P450 Enzymes in Drug-Drug Interactions.J.M. Sauer, E.R. Stine, L. Gunawardhana, D.A. Hill, and I.G. Sipes, The Liver as a Target for Chemical-Chemical Interactions.A.D. Rodrigues and S.L. Wong, Applications of Human Liver Microsomes in Metabolism-Based Drug-Drug Interactions.A.P. Li, Applications of Human Hepatocytes as an Experimental System for the Evaluation of Pharmacokinetic Drug-Drug Interactions.J.L. Ferrero and K. Brendal, Liver Slices as a Model in Drug Metabolism and Drug-Drug Interactions.C.L. Crespi and B.W. Penman, The Use of cDNA Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions.G.L. Kedderis, Pharmacokinetics of Drug Interactions.T.N. Thompson, Experimental Models for Evaluating Enzyme Induction Potential of New Drug Candidates in Animals and Man and a Strategy for Their Use.J.D. Balian, Metabolic Drug-Drug Interactions: Perspective from U.S. FDA Medical and Clinical Pharmacology Reviewers.M. Jurima-Romet, Drug Interactions: Perspectives of the Canadian Directorate.

Reviews

"Praise for the Series ""Recommended not only to pharmacologists but also to all those in related disciplines."" --NATURE ""The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated."" --H.E. Kaufmann in CHEMOTHERAPY ""Superb reading material."" --JOURNAL OF PHARMACEUTICAL SCIENCES ""This book represents a comprehensive review of drug-drug interaction and is unique since the contributors are from all facets of the workplace, including academic institutes, government, and industry... The most attractive feature of the book is its well-focused subject area with the emphasis on the importance of P-450 enzymes in drug interactions and how government regulatory agencies evaluate them... It is unique since it presents the regulatory aspects of drug evaluations as an integral part of the science of drug-drug interactions."" --Rajendar Mehta, PhD, University of Illinois at Chicago College of Medicine for DOODY'S PUBLISHING"

"Praise for the Series""Recommended not only to pharmacologists but also to all those in related disciplines."" --NATURE ""The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated."" --H.E. Kaufmann in CHEMOTHERAPY ""Superb reading material."" --JOURNAL OF PHARMACEUTICAL SCIENCES ""This book represents a comprehensive review of drug-drug interaction and is unique since the contributors are from all facets of the workplace, including academic institutes, government, and industry... The most attractive feature of the book is its well-focused subject area with the emphasis on the importance of P-450 enzymes in drug interactions and how government regulatory agencies evaluate them... It is unique since it presents the regulatory aspects of drug evaluations as an integral part of the science of drug-drug interactions."" --Rajendar Mehta, PhD, University of Illinois at Chicago College of Medicine for DOODY'S PUBLISHING"

Praise for the Series Recommended not only to pharmacologists but also to all those in related disciplines. --NATURE The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated. --H.E. Kaufmann in CHEMOTHERAPY Superb reading material. --JOURNAL OF PHARMACEUTICAL SCIENCES This book represents a comprehensive review of drug-drug interaction and is unique since the contributors are from all facets of the workplace, including academic institutes, government, and industry... The most attractive feature of the book is its well-focused subject area with the emphasis on the importance of P-450 enzymes in drug interactions and how government regulatory agencies evaluate them... It is unique since it presents the regulatory aspects of drug evaluations as an integral part of the science of drug-drug interactions. --Rajendar Mehta, PhD, University of Illinois at Chicago College of Medicine for DOODY'S PUBLISHING

Author Information

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children. Joseph T. Coyle, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA Albert Li, MD, Professor of Paediatrics and Person-in-charge of the Respiratory Service in the Department of Paediatrics at the Chinese University of Hong Kong

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