Overview

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease, Second Edition delves into the complexities of drug discovery, specifically for Alzheimer's Disease, presenting the necessary paradigm for future success in research and treatment. This edition is thoroughly updated with recent developments in therapeutic strategies, including amyloid hypothesis, tau, apo E, insulin, and others, and introduces a new chapter on drug delivery to the brain. Additionally, the book encompasses diagnosis, epidemiology, drug discovery strategies, current therapeutics, and more, offering a comprehensive approach to Alzheimer's Disease. It covers the latest in targeted drug design, preclinical studies, and animal models, making it an essential resource for pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers. Patients and advocacy groups can also gain valuable insights from the overview of current treatments and scientific advancements in the field.

Full Product Details

Author:   Adeboye Adejare (Professor, Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Edition:   2nd edition
Weight:   0.450kg
ISBN:  

9780443300080

ISBN 10:   0443300089
Pages:   480
Publication Date:   12 November 2025
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. Neurodegenerative disorders: why do we need new therapies? 2. Cognitive and functional considerations in Alzheimer’s disease diagnosis 3. National plan and resources to address Alzheimer’s disease 4. Biosensor approaches in the diagnosis of a neurodegenerative disorder 5. Current therapies for the treatment of Alzheimer’s disease: small molecules - Acetylcholine esterase inhibitors and NMDA receptor antagonist 6. Physicochemical properties for potential AD drugs 7. Receptor targets in Alzheimer’s disease drug discovery 8. Amyloid hypothesis in the development of therapeutic agents for Alzheimer’s disease 9: Tau proteins 10. Cholesterol and fat metabolism in Alzheimer’s disease 11. Mitochondria as a therapeutic target for the treatment of Alzheimer’s disease 12. Peptide-based therapeutics 13. Anti-inflammatory and immunomodulating agents 14. Prion and other protein folding hypotheses 15. Simple in vivo models of Alzheimer’s disease 16. Rodent models for Alzheimer’s disease drug discovery 17. Drug delivery to the brain 18. Alzheimer’s disease drugs in clinical trials 19. Biologics for the treatment of Alzheimer’s disease 20. Brain health 21. Non-pharmacologic treatment approaches

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Author Information

Adeboye Adejare’s research group is interested in the areas of design and syntheses of small organic molecules to probe neurodegeneration, especially Alzheimer’s disease, and for treatment of cancer. They are also interested in in vitro models of drug absorption and ability to cross blood brain barrier; drug targeting; pharmaceutical profiling; and chemistry of fluoroaromatic compounds. The research is funded by the National Institutes of Health, the Office of Naval Research, and several pharmaceutical companies. These efforts have resulted in over 50 publications, 5 patents, and over 100 presentations at meetings, including invited presentations at national and international conferences. He also serves on several national panels, including those by NIH, NSF, and Alzheimer’s Association. Dr. Adejare is the editor of Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease which is also published by Elsevier.

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