Overview

Dosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries.

Full Product Details

Author:   Rakesh Kumar Tekade, PhD (Assistant Professor, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research Ahmedabad, Gujarat, India)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   2.220kg
ISBN:  

9780128144237

ISBN 10:   0128144238
Pages:   820
Publication Date:   27 July 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Preformulation in drug research and pharmaceutical product development 2. Physicochemical aspects to be considered in Pharmaceutical Product Development 3. Role of physicochemical parameters on drug absorption and their Implications in Pharmaceutical Product Development 4. Physiologic Factors Related to Drug Absorption 5. Physico-chemical, pharmaceutical and biological considerations in GIT Absorption of drugs 6. Influence of Drug Properties and Routes of Drug Administration on the design of controlled release systems 7. Drug stability and degradation studies 8. First pass metabolism considerations in Pharmaceutical Product Development 9. Dissolution profile considerations during Pharmaceutical Product Development 10. Drug disposition considerations in Pharmaceutical Product Development 11. Protein and tissue binding: Implication on pharmacokinetic parameters 12. Preformulation studies of drug substances, proteins and peptides: Role in drug discovery and Pharmaceutical Product Development 13. Role of salt selection in drug discovery and development 14. Drug Complexation: Implications in drug solubilization and oral bioavailability enhancement 15. Solubility and solubilization approaches in Pharmaceutical Product Development 16. Rheology and its implications on performance of liquid dosage forms 17. Micromeritics in Pharmaceutical Product Development 18. Four stages in Pharmaceutical Product Development – Preformulation – Prototype development - Biological aspects - Scale up studies – Commercialization  19. Scale up studies in Pharmaceutical Product Development 20. Manipulation of physiological processes for Pharmaceutical Product Development 21. Impact of pharmaceutical product Quality on Clinical Efficacy 22. Formulation additives used in Pharmaceutical Products: Emphasis on regulatory perspectives and GRAS

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Author Information

Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.

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