Overview

At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of targeted therapeutics is also addressed. At least 160 proteins are involved in replicating the human genome, and at least 40 diseases are caused by aberrant DNA replication, 35 by mutations in genes required for DNA replication or repair, 7 by mutations generated during mitochondrial DNA replication, and more than 40 by DNA viruses. Consequently, a growing number of therapeutic drugs are targeted to DNA replication proteins. This authoritative volume provides a rich source of information for researchers, physicians, and teachers, and will stimulate thinking about the relevance of DNA replication to human disease.

Full Product Details

Author:   Melvin L. DePamphilis
Publisher:   Cold Spring Harbor Laboratory Press,U.S.
Imprint:   Cold Spring Harbor Laboratory Press,U.S.
Edition:   2nd Revised edition
Volume:   No. 47
Dimensions:   Width: 16.10cm , Height: 4.50cm , Length: 23.60cm
Weight:   1.400kg
ISBN:  

9780879697662

ISBN 10:   0879697660
Pages:   814
Publication Date:   25 July 2006
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

PART I: CELLULAR DNA REPLICATION Chapter 1. Duplication of DNA in Eukaryotic Cells Thomas J. Kelly and Bruce Stillman Chapter 2. Eukaryotic DNA Replication Origins Mirit I. Aladjem, Arturo Falasch, and David Kowalski Chapter 3. Assembly of Pre-replication Complexes Umasundari Sivaprasad, Anindya Dutta, and Stephen P. Bell Chapter 4. Activation of Pre-replication Complexes Johannes C. Walter & Hiroyuki Araki Chapter 5. Eukaryotic DNA Replication Forks Peter M.J. Burgers and Yeon-Soo Seo Chapter 6. Chromatin Assembly Paul D. Kaufman & Genevi e8;ve Almouzni Chapter 7. Inheritance of Genomic Methylation Patterns Robert A. Rollins, Marc Damelin, and Timothy H. Bestor Chapter 8. Termination of DNA Replication Deepak Bastia and Bidyut K. Mohanty Chapter 9. DNA Replication and Nuclear Architecture David M. Gilbert and Susan M. Gasser Chapter 10. Temporal Order of DNA Replication Anne D. Donaldson and Carl L. Schildkraut Chapter 11. DNA Replication during Animal Development and Its Relevance to Gene Expression Damien Gr e9;goire and Marcel M e9;chali Chapter 12. Developmental Gene Amplification Brian R. Calvi Chapter 13. Plant Cells and Viruses Crisanto Gutierrez Chapter 14. Archaeal, Bacterial, and Eukaryal DNA Replication Machines Stephen D. Bell PART II: REGULATION OF DNA REPLICATION AND CELL PROLIFERATION Chapter 15. Regulating Initiation Events in Yeasts Etienne Schwob and Karim Labib Chapter 16. Regulating Initiation Events in Metazoa Melvin L. DePamphilis and J. Julian Blow Chapter 17. Responses to Aberrant DNA Replication and DNA Damage in Yeasts Marco Foiani, Sanjay Kumar, and Joel A. Huberman Chapter 18. Responses to Aberrant DNA Replication and DNA Damage in Metazoa Jean Gautier and Jiri Bartek PART III: CELLULAR DNA REPLICATION AND HUMAN DISEASE Chapter 19. DNA Damage and Human Disease Errol C. Friedberg Chapter 20. DNA Polymerases and the Fidelity of DNA Replication Polina V. Shcherbakova and Thomas A. Kunkel Chapter 21. The Role of RF-C and PCNA Proteins in Maintaining Genomic Stability Toshiki Tsurimoto Chapter 22. DNA Helicases and Human Disease Ashwini S. Kamath-Loeb, Michael Fry, and Lawrence A. Loeb Chapter 23. DNA Replication, Repeat Instability, and Human Disease John D. Cleary, Albert R. La Spada, and Christopher E. Pearson Chapter 24. DNA Replication and Cancer William C. Burhans, Antony M. Carr, and Geoffrey M. Wahl Chapter 25. Cancer Diagnosis and DNA Replication Nicholas Coleman, Anthony D. Mills, and Ronald A. Laskey Chapter 26. Pharmacological Agents That Target DNA Replication Yves Pommier and Robert B. Diasio Chapter 27. Mitochondrial DNA Replication and Human Disease David A. Clayton and Nils-G f6;ran Larsson Chapter 28. Telomere DNA Replication, Telomerase, and Human Disease David C.F. Sealey, Virginia A. Zakian, and Lea Harrington PART IV: VIRAL DNA REPLICATION AND HUMAN DISEASE Chapter 29. Parvovirus Susan F. Cotmore and Peter Tattersall Chapter 30. Papillomavirus Louise T. Chow and Thomas R. Broker Chapter 31. Polyomavirus Ellen Fanning and James M. Pipas Chapter 32. Adenovirus Peter C. van der Vliet and Rob C. Hoeben Chapter 33. Herpes Simplex Virus Sandra K. Weller and Donald M. Coen Chapter 34. Epstein-Barr Virus Wolfgang Hammerschmidt and Bill Sugden Chapter 35. Poxvirus Bernard Moss and Frank De Silva Chapter 36. Hepadnavirus Christoph Seeger and William S. Mason APPENDIX 1 A. Molecular Interaction Maps of DNA Replication Mirit I. Aladjem and Kurt W. Kohn B. The Evolutionary History of Proteins Involved in Pre-replication Complex Assembly Lakshminarayan M. Iyer and L. Aravind APPENDIX 2 Table I. Size and Complexity of Eukaryotic Genomes Table II. Names and Abbreviations for Organisms, Genes and Protein Complexes Table III. Nomenclature for Proteins and Protein Complexes in Different Organisms Table IVA. Phyletic Distribution of Proteins Involved in Pre-replication Complex Assembly Table IVB. Alternative Names for Orthologs Table V. Cellular Concentrations of Replication Origins and Pre-replication Complex Proteins Table VI. Human Diseases Associated with Defects in DNA Replication and Repair Table VII. Therapeutic Drugs That Target DNA Replication

Reviews

...this book provides a broad and current synthesis of our understanding of genome duplication and it should be on the bookshelves of all students of DNA replication. Nature Cell Biology

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