Overview

The preservation of expected life span and longevity, as well as the assurance of life succession among all species requires the integrity and faithful transcription of DNA. A dedicated machinery of DNA repair factors is responsible for reversing DNA damage across the genome. Efficient response to various effectors of DNA damage is also dependent on a complex network of sensors and mediators of stress signals which are upstream of DNA repair activation and together constitute components of the DNA damage response (DDR). This book reviews research on cell cycle checkpoints as essential mechanisms for safeguarding genome stability; nucleotide excision repair (NER) which recognises and removes bulky DNA damage that leads to DNA double-helix distortion and others.

Full Product Details

Author:   Allison E Thomas
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Weight:   0.716kg
ISBN:  

9781616689148

ISBN 10:   1616689145
Pages:   287
Publication Date:   24 October 2011
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Awaiting stock  
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Table of Contents

Preface; Recent Advances on DNA Damage, its Repair & Genomic Stability of Green Algae Chlamydomonas Reinhardtii & other Photoautotrophic Eukaryotes; DNA Instability in Premature Aging; Intra S-Phase Checkpoint; Multiplex Cell Free Assays to Apprehend DNA Repair Responses: Application to Aging Study; 7, 8-Dihydro-8-oxoguanine, A Major Form of Oxidative DNA Damage, & its Repair System; Participation of Heat Shock Proteins in DNA Repair Mechanisms in Cancer; DNA Damage Repair in Testicular Germ Cells of Aging Men; Nucleotide-Excision Repair Deficiency: A Causative Factor for Accelerated Aging Diseases in Humans?; Historical Development of Uncaria Preparations & their Related Bioactive Components; DNA Damage Response & Repair: Mechanisms in Aging & Cancer; DNA Repair Gene XPC Codon 939 Polymorphism & AFB1-Related Hepatocellular Carcinoma Risk in Guangxi Population, China; Influence of Age on Expresion of DNA Repair Genes in Arabidopsis; Index.

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